In the development of anti-cancer drugs, ensuring the safety of these medications is our primary mission. By offering cardiotoxicity and inflammation reaction testing services, Creative Biolabs can assist drug development teams in identifying potential toxicity and adverse reactions during the early screening phase, ultimately reducing research and development costs. At present, we are capable of identifying and quantifying the inflammatory reactions triggered by anti-tumor drugs, allowing us to predict their potential impact on cardiac function.

Introduction

Recent studies have increasingly indicated that inflammation is not only a significant mechanism behind heart disease, but it may also play a crucial role in the cardiac toxicity associated with certain cancer therapies. Some anticancer drugs can trigger an inflammatory reaction in the body, resulting in the upregulation of inflammatory factors, such as cytokines and chemokines, in cardiac tissue. The release of these inflammatory substances can result in damage to the heart muscle and hurt cardiac function.

Recently, Creative Biolabs has been dedicated to identifying early-warning biomarkers to assess the cardiotoxicity associated with cancer treatments. Certain inflammation-related biomarkers, such as C-reactive protein and tumor necrosis factor-alpha, have already become standard evaluation metrics. Additionally, we are delving deeper into the specific mechanisms by which inflammation contributes to cardiotoxicity, including the activation of cellular signaling pathways and the interactions between inflammatory factors and cardiac myocytes.

Fig.1 Cancer Drug-Induced Infammation.^1,3

Services

Creative Biolabs offers cutting-edge solutions for detecting inflammatory reactions, aimed at helping clients quickly and effectively evaluate biomarkers and mechanisms related to inflammation during cancer drug development. We leverage the latest technologies, including high-throughput screening, precise sequencing techniques, and multiplex testing platforms, to ensure the accuracy and reliability of our results. By collaborating closely with our clients, we are dedicated to accelerating the process of inflammation reaction detection services, providing robust scientific support for new anti-tumor drug development.

1. Serological Testing:

CRP Testing: CRP is an acute-phase reactant that rises rapidly during inflammation, commonly utilized to assess the severity of infection or inflammation.

Cytokine Testing: Measurement of cytokines such as Tumor Necrosis Factor (TNF-α) and Interleukins (IL-1, IL-6) provides insights into the inflammatory microenvironment and cellular interactions.

2. Biomarker Analysis:

White Blood Cell Count: Standard blood tests can determine white blood cell levels in peripheral blood; elevated counts are typically associated with infection or inflammation.

ESR Test: Our ESR test assesses the speed at which red blood cells fall, indicating ongoing inflammation or infection.

3. Molecular Biology Testing:

Gene Expression Analysis: Utilizing techniques such as qPCR and gene chips, changes in the expression of genes related to inflammation can be monitored, aiding in the understanding of inflammatory mechanisms.

Exosome Analysis: Studying extracellular vesicles (exosomes) for their miRNA and protein content offers information about intercellular communication to inflammation.

4. Imaging Techniques:

Ultrasound, CT, and MRI: Imaging modalities can visualize inflammation in tissues and organs, assisting in the assessment of the extent of inflammation associated with specific diseases.

5. Other Techniques:

Mass Spectrometry: Employed for the detection and quantification of metabolites associated with inflammation, helping to elucidate metabolic characteristics of the condition.

Autoimmune Testing: For certain autoimmune diseases, inflammation status can be evaluated through antibody testing and other related methods.

Fig.2 A C-Reactive Protein Detection System.^2,3

Features

• Technological Diversity: The ability to assess inflammatory reactions from multiple angles and levels provides a more comprehensive understanding.
• High Throughput: Certain molecular biology techniques, such as gene chips, allow for the simultaneous detection of multiple inflammation-related markers, thereby enhancing efficiency.
• Sensitivity and Specificity: Innovative technologies like mass spectrometry and exosome analysis improve detection sensitivity and specificity, aiding in early diagnosis.
• Convenience: Serological tests are typically quick and straightforward, making them suitable for routine screening and regular monitoring.
• Dynamic Monitoring: These methods enable regular tracking of inflammatory changes, facilitating the evaluation of treatment efficacy and disease progression.
• Combination of Various Testing Methods: By integrating different testing approaches, a more holistic assessment of inflammation can be achieved.

Creative Biolabs offers specialized services for detecting inflammation reactions related to cardiotoxicity in anti-cancer drugs, to assist pharmaceutical companies and research institutions in more effectively assessing the safety of their medications. Till now, our services not only aid in optimizing drug formulations and reducing the risk of adverse reactions but also enhance the market competitiveness of the medication. If you are interested in our inflammation reaction testing services related to cardiotoxicity, or if you would like to learn more, please don't hesitate to contact us.

References

1. Hutchins, Elizabeth, Eric H. Yang, and Ashley F. Stein-Merlob. "Inflammation in Chemotherapy-Induced Cardiotoxicity." Current Cardiology Reports (2024): 1-12.
2. Chuang, Chih-Shen, et al. "A smartphone-based diffusometric immunoassay for detecting C-reactive protein." Scientific Reports 9.1 (2019): 17131.
3. Distributed under Open Access license CC BY 4.0, without modification.

For Research Use Only | Not For Clinical Use