PharmaOnco™ HEK293-Tg(Human CD137)-NF-κB Reporter Cell Line, Single Clone (CAT#: ITS-0822-HMM108)

Creative Biolabs offers HEK293-Tg(Human CD137)-NF-κB reporter cell line which the CD137 gene stably expressed in NF-κB reporter HEK293 cells.

The HEK293-Tg(Human CD137)-NF-κB reporter cell line is a cell line that has been genetically engineered to express the human CD137 receptor and a reporter gene that is under the control of the NF-κB signaling pathway. CD137, also known as 4-1BB, is a co-stimulatory receptor that plays a key role in regulating immune responses. The NF-κB pathway is a critical signaling pathway involved in the regulation of immune and inflammatory responses. This cell line can be used to investigate the effects of various compounds or treatments on NF-κB signaling and to screen for potential therapeutic agents that modulate this pathway.

Consistent gene expression;
Reliability and reproducibility;

Functional assay

CD137

Human

HEK293

GenBank accession #NM_001561

CD137, also known as 4-1BB, is a protein-coding gene that encodes a cell surface receptor that is part of the tumor necrosis factor receptor superfamily. CD137 is primarily expressed on activated T cells, natural killer cells, dendritic cells, and monocytes, and plays a key role in regulating immune responses. Activation of CD137 by its ligand, CD137L, leads to the activation of downstream signaling pathways that stimulate T cell proliferation, survival, and cytokine production. This activation enhances immune responses against pathogens and cancer cells. CD137 has been implicated in the modulation of autoimmune diseases, as well as in the promotion of anti-tumor immunity.