PharmaOnco™ HEK293-Tg(Human OX40)-NF-κB Luc Reporter Cell Line, Single Clone (CAT#: ITS-0822-HMM187)

Creative Biolabs offers HEK293-Tg(Human OX40)-NF-κB Luc reporter cell line which the OX40 gene stably expressed in NF-κB Luc reporter HEK293 cells.

HEK293-Tg(Human OX40)-NF-κB Luc reporter cell line is a genetically modified HEK293 cell line that stably expresses the human OX40 receptor and a luciferase reporter gene downstream of the NF-κB promoter. This cell line is commonly used in research to study the activation of the NF-κB signaling pathway in response to OX40 stimulation.

Consistent gene expression;
Reliability and reproducibility;

Functional assay

OX40

Human

HEK293

GenBank Accession #NM_003327

The OX40 gene, also known as TNFRSF4, is a gene that encodes a protein known as OX40 (CD134). OX40 is a member of the tumor necrosis factor receptor superfamily and is primarily expressed on activated T cells. When OX40 binds to its ligand, OX40L, it plays a critical role in regulating T cell activation, proliferation, survival, and cytokine production. The OX40 gene has been implicated in various immune responses, including promoting T cell activation and survival, enhancing memory T cell formation, and regulating the balance between effector and regulatory T cells. Targeting the OX40 pathway has shown promise in cancer immunotherapy, as blocking OX40 signaling can enhance anti-tumor immune responses.