PharmaOnco™ HEK293-Tg(Human OX40) Stable Cell Line, Single Clone (CAT#: ITS-0822-HMM186)

Creative Biolabs offers HEK293-Tg(Human OX40) stable cell line which the OX40 gene stably expressed in HEK293 cells.

HEK293-Tg(Human OX40) stable cell line is a cell line derived from HEK293 cells that has been transfected with the human OX40 gene and stably expresses this gene. OX40, also known as CD134, is a co-stimulatory molecule that plays a role in regulating immune responses, particularly T cell activation and function. The creation of this stable cell line allows for the study of OX40 signaling pathways, interactions with other immune cells, and potential therapeutic interventions targeting OX40. It can be used in various research applications, such as screening for OX40 agonists or antagonists, studying the effects of OX40 on immune responses, and investigating the role of OX40 in different disease models.

Consistent gene expression;
Reliability and reproducibility;

Functional assay

OX40

Human

HEK293

GenBank Accession #NM_003327

The OX40 gene, also known as TNFRSF4, is a gene that encodes a protein known as OX40 (CD134). OX40 is a member of the tumor necrosis factor receptor superfamily and is primarily expressed on activated T cells. When OX40 binds to its ligand, OX40L, it plays a critical role in regulating T cell activation, proliferation, survival, and cytokine production. The OX40 gene has been implicated in various immune responses, including promoting T cell activation and survival, enhancing memory T cell formation, and regulating the balance between effector and regulatory T cells. Targeting the OX40 pathway has shown promise in cancer immunotherapy, as blocking OX40 signaling can enhance anti-tumor immune responses.