PharmaOnco™ Jurkat-TCR KO Cell Line, Single Clone (CAT#: ITS-0822-HMM207)

Creative Biolabs offers Jurkat-TCR KO cell line which the TCR gene was knocked out in Jurkat cells.

The Jurkat-TCR KO cell line is a type of Jurkat cell line that has been subjected to targeted knockout of the T cell receptor (TCR) genes. This results in a cell line that is unable to express functional TCRs on its surface, making it a valuable tool for studying T cell receptor signaling pathways and functions. Researchers can use Jurkat-TCR KO cell line to investigate the role of TCR signaling in cellular processes such as activation, proliferation, differentiation, and cytokine production. This cell line can also be used in drug screening assays to identify compounds that target TCR signaling pathways.

Loss of gene function;
Stability and Specificity;
Reliability and reproducibility;

Functional assay

TCR

Human

Jurkat

The TCR gene, or T-cell receptor gene, is a gene responsible for encoding the protein receptors on the surface of T cells. T cells are a type of white blood cell that play a central role in the immune system, recognizing and responding to foreign antigens such as viruses, bacteria, and cancer cells. There are two main types of TCR genes, alpha and beta, which combine to form the T-cell receptor complex. These receptors are highly diverse and can recognize a wide variety of antigens, allowing T cells to mount specific immune responses to different threats. Mutations or dysregulation of the TCR gene can lead to immune system dysfunction, resulting in conditions such as autoimmune diseases, immunodeficiency disorders, and cancer. Studying the TCR gene and its role in immune function is important for understanding and developing treatments for these conditions.