PharmaOnco™ Jurkat-Tg(Mouse PD-1)-NFAT Luc Reporter Cell Line, Single Clone (CAT#: ITS-0822-HMM189)

Creative Biolabs offers Jurkat-Tg(Mouse PD-1)-NFAT Luc reporter cell line which the PD-1 gene stably expressed in NFAT Luc reporter Jurkat cells.

The Jurkat-Tg(Mouse PD-1)-NFAT Luc reporter cell line is a specialized cell line that has been genetically engineered to express a luciferase reporter gene under the control of the nuclear factor of activated T-cells (NFAT) response element. This cell line also expresses the mouse programmed cell death protein 1 (PD-1) receptor, which can be activated by its ligands to regulate T-cell activation and function. This cell line is commonly used in research to study the role of PD-1 signaling in T-cell activation and function, particularly in the context of immune responses and autoimmune diseases

Consistent gene expression;
Reliability and reproducibility;

Functional assay

PD-1

Mouse

Jurkat

GenBank Accession #NM_008798

The PD-1 gene, also known as programmed cell death protein 1, is a gene that encodes a protein found on the surface of T cells and other immune cells. PD-1 plays a crucial role in regulating the immune response by inhibiting T cell activity and preventing autoimmunity. However, overexpression of PD-1 can also suppress the immune response against cancer cells, allowing tumors to evade detection and destruction by the immune system. Therapies targeting PD-1, such as checkpoint inhibitors, have been developed to block the interaction between PD-1 and its ligands, releasing the brakes on the immune response and helping the body's immune system to attack and eliminate cancer cells. These treatments have shown significant success in treating various types of cancer, including melanoma, lung cancer, and lymphoma.