Creative Biolabs specializes in evaluating the cardiotoxic effects and microvascular damage caused by anti-cancer drugs. We conduct our research using small animal models, such as mice and rats, to examine the impact of these agents on the heart and microvasculature. Furthermore, we focus on the detection of biomarkers to identify characteristics associated with microvascular injury in the heart, providing a scientific foundation for assessing therapeutic efficacy.

Introduction

Research indicates that cancer therapies may intensify cardiotoxicity by inducing microvascular damage. These anti-cancer agents can potentially disrupt endothelial cell function, resulting in alterations to the structure and function of microvessels, which in turn can affect blood flow to the heart and other organs. In this case, there is a reciprocal mechanism at play between the cardiotoxicity caused by anticancer drugs and the microvascular injuries they induce.

Creative Biolabs offers a series of CRO analysis services for microvascular damage associated with cardiotoxicity. Our focus is on evaluating the impact of anti-cancer agents or treatments on cardiac microvasculature, particularly during the drug development phase. We ensure effective monitoring of cardiac side effects in the treatment of cardiovascular diseases and cancer.

Fig.1 Microvascular Complications Prediction Systems.^1,3

Services

At Creative Biolabs, our services encompass preclinical research, which includes well-mature analysis through animal model experiments and histopathology. Utilizing mouse, rat, and large animal models, and applying techniques such as H&E staining and immunohistochemistry, we accurately assess changes in microvascular structures.

Additionally, we offer a range of biomarker assays to analyze relevant indicators in blood and cardiac tissues, such as troponin and BNP, enabling you to gain a comprehensive understanding of cardiac damage. By employing echocardiography, as well as MRI and CT imaging, we can visually evaluate cardiac function and microvascular structure to ensure you have a holistic view of heart health.

To gain further insights into the effects of drugs on the heart, we conduct detailed functional studies, including pressure-volume loops and heart rate variability analysis, while monitoring hemodynamic changes. Our cellular and molecular mechanisms research involves cell culture experiments and signaling pathway analysis to explore key processes such as oxidative stress and inflammatory responses. Through these services, we are committed to providing comprehensive support in drug development, helping you to safely and efficiently advance cardiovascular-related therapeutics.

Fig.2 Microvascular pathology Analysis of WMH and NAWM.^2,3

Procedures

STEP1: Research Design and Planning: We will develop a scientifically sound research plan that outlines the experimental objectives and parameters, including the assessment metrics for microvascular damage and the selection of appropriate research models.

STEP2: Establishment of Animal Models: We will select suitable animal models (such as mice or rats) to replicate the physiological and pathological characteristics of human microvascular injury, enabling the evaluation of the microvascular toxicity of anticancer drugs.

STEP3: Drug Administration Protocols: Creative Biolabs will design studies with varying dosages and routes of administration to accurately assess the impact of anticancer medications on microvessels and to observe dose-response relationships.

STEP4: Assessment of Damage: Using methods such as histological examination, imaging analysis, and biochemical indicator evaluation, our scientists will analyze the extent of microvascular damage, including changes in vascular permeability and hemodynamics.

STEP5: Investigation of Molecular Mechanisms: Our laboratory will delve into the molecular mechanisms by which anticancer drugs induce microvascular damage, exploring pathways like inflammatory response and oxidative stress, thereby providing theoretical support for subsequent clinical studies.

STEP6: Data Analysis and Reporting: We will conduct a statistical analysis of the experimental data to comprehensively evaluate the extent of microvascular damage and its correlation with the drugs, resulting in detailed research reports that serve as a foundation for assessing drug safety.

Creative Biolabs offers analysis services to assess the effects of specific anticancer drugs on the heart and microvasculature. We can conduct in vitro studies to evaluate the cardiotoxicity and risk of microvascular damage associated with potential drug candidates. Besides, we are capable of developing and validating biomarkers for the early detection of cardiotoxicity and microvascular damage. If you are interested in our analytical services related to the cardiotoxicity and microvascular damage caused by anti-cancer drugs, we encourage you to contact us directly.

References

1. Al-Sari, Naba, et al. "Precision diagnostic approach to predict 5-year risk for microvascular complications in type 1 diabetes." EBioMedicine 80 (2022).
2. Solé-Guardia, Gemma, et al. "Three-dimensional identification of microvascular pathology and neurovascular inflammation in severe white matter hyperintensity: a case report." Scientific Reports 14.1 (2024): 5004.
3. Distributed under Open Access license CC BY 4.0, without modification.

For Research Use Only | Not For Clinical Use