The Importance of Nucleotide Synthesis Inhibitor Development

Cancer cells exhibit a significant change in their metabolic processes, leading to altered metabolism. One prominent characteristic is their increased production and utilization of nucleotide triphosphates, which is a consistent metabolic reliance observed across various cancer types and genetic variations. This heightened nucleotide metabolism plays a vital role in fueling several aggressive behaviors of cancer cells, such as uncontrolled cell growth, resistance to chemotherapy, evasion of the immune system, and the ability to spread and form distant metastases. As a result, inhibiting the nucleotide synthesis sheds light on cancer treatment.

Fig.1 The interaction between nucleotide metabolism and immunity used in the clinic.¹

Our Nucleotide Synthesis Inhibitor Development Service for Cancer Immunotherapy

Leveraging our wealth of expertise and experience, Creative Biolabs globally provides a nucleotide synthesis inhibitor development service for cancer immunotherapy to facilitate the discovery and development of new cancer therapeutic agents. Whether you're doing fundamental research and discovery, or compound screening, Creative Biolabs is well-positioned to assist you speed your cancer research and anticancer medication development efforts.

Our nucleotide synthesis inhibitor development service for cancer immunotherapy covers all stages of pre-clinical development, which includes target screening, evaluating efficacy and toxicity, and conducting IND-enabling studies. This service provides our customers with a range of 3D cell culture models using state-of-the-art techniques to assess compounds that impact the physiological activities of cancer cells. In addition, we also utilize advanced high-content imaging to analyze the cellular response to treatments, stimuli, or alterations in protein expression, allowing us to examine the specific effects of compound treatments on different cell populations. Our team at Creative Biolabs collaborates closely with our customers to devise the most effective strategies and techniques for assessing and optimizing lead candidates for development.

Fig.2 Workflow of nucleotide synthesis inhibitor development service for cancer immunotherapy.

In Vivo Study Models for Nucleotide Synthesis Inhibitor Development

We provide a series of in vivo study models that have been constructed to help validate the efficacy of inhibitors under tumor-related physiological conditions:

• Immuno-Oncology Tumor Models
• Xenograft Tumor Models
• Hollow Fiber Model
• Orthotopic Tumor Models

Popular Targets Available at Creative Biolabs

Benefits for You

• Experienced scientists and clinicians bring your idea from concept to reality in the medical field.
• Excelling in developing and producing pharmaceuticals.
• Highly efficient in inhibitor development with great accuracy.
• Lower costs and shorter timelines.
• One-stop customized development service.

Discover the future of cancer immunotherapy with our advanced nucleotide synthesis inhibitor development service. Contact us without hesitation for high-quality solutions.

Reference

1. Wu, Huai-liang, et al. "Targeting nucleotide metabolism: a promising approach to enhance cancer immunotherapy." Journal of Hematology & Oncology 15.1 (2022): 1-21.

For Research Use Only | Not For Clinical Use