Short Decsription
This product is a PAH-targeted RNA modification and metabolomics analysis tool based on the ac4C (METTL16-YTHDF3-FTO-HDACs-phos) modification and Mevalonate pathway-mediated (ATAXIN-2-Succinyl-CoA-ADP) metabolic analysis system.
RNA writers
METTL16
RNA readers
YTHDF3
RNA erasers
FTO
Enzymes
HDACs
RNA types
tRNA
Modification
ac4C
Label
phos
RNA editing
G to A
Cell Type
M2 macrophages
Oligonucleotide
2'-OMe, 2'dT (LNP)
RNA Construction
tRNA-ac4C-METTL16-YTHDF3-FTO-HDACs-phos
Substrates
Succinyl-CoA
Cofactors
ADP
Pathway
Mevalonate pathway
Epigenetic regulator
SETD2 deficiency
Metabolic alteration
Upregulating oxidative phosphorylation andfatty acid synthesis
Targeting diseases
Adrenocortical carcinoma
RNA-binding proteins
ATAXIN-2
Metabolic Reprogramming
Mevalonate pathway-ATAXIN-2-Succinyl-CoA-ADP

For Research Use Only | Not For Clinical Use

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