Short Decsription
This product is a Protein disulfide-isomerase-targeted RNA modification and metabolomics analysis tool based on the ac4C (METTL14-YTHDF2-ALKBH5-ACSS2-spacer C9) modification and TCA cycle-mediated (RBFOX1-Succinyl-CoA-α-KG) metabolic analysis system.
Oligonucleotide
2'-OMe, 2'dT (LNP)
RNA Construction
tRNA-ac4C-METTL14-YTHDF2-ALKBH5-ACSS2-spacer C9
Epigenetic regulator
PKCλ/ι deficiency
Metabolic alteration
Favor the development of NEPC characteristics
Targeting diseases
Renal and Bladder Cancers
RNA-binding proteins
RBFOX1
Metabolic Reprogramming
TCA cycle-RBFOX1-Succinyl-CoA-α-KG