IL-2-expressing Oncolytic Herpes Simplex Virus 1 (ΔΔICP0), CMV-IL-2(Cat#: CyOV-0055XY)
DatasheetThis product is a IL-2 expressing oncolytic herpes simplex virus, which is based on HSV-1 with ICP0 deleted. The deletion of ICP0 were attenuated for viral growth, and impaired for viral reactivation when equivalent latent infections were established in vivo. This product can be used in oncolytic virotherapy research and further recombinant HSV construction.
Specifications | |
|---|---|
| Family | Herpesviridae |
| Species | Herpes simplex virus |
| Serotype | Herpes simplex virus 1 |
| Backbone | HSV-1 (ΔΔICP0) |
| Backbone Background | Herpes simplex virus 1 and 2 (HSV-1 and HSV-2), also known as human herpesvirus 1 and 2 (HHV-1 and HHV-2), are two members of the human Herpesviridae family, a set of viruses that produce viral infections in the majority of humans. Modified Herpes simplex virus is considered as a potential therapy for cancer and has been extensively clinically tested to assess its oncolytic ability. |
| Gene Modification | ΔΔICP0 |
| Promoter | CMV |
| Transgene | IL-2 |
| Type of Transgene | Cytokine |
| Related Target/Protein | Interleukin 2 |
| Capsid Modification | None |
| Titer | >1*10^8 PFU |
| Related Diseases | Osteosarcoma |
Transgene | |
|---|---|
| Alternative Names | IL-2, IL2, TCGF, lymphokine, interleukin 2 |
| Gene ID | 3558 |
Information | |
|---|---|
| Introduction | Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a 15,5 - 16 kDa protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes. The major sources of IL-2 are activated CD4+ T cells, activated CD8+ T cells, NK cells, dendritic cells and macrophages. |
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