IL-4-expressing Oncolytic Herpes Simplex Virus 1 (ΔΔICP0), SV40-IL-4(Cat#: CyOV-0266XY)
DatasheetThis product is a IL-4 expressing oncolytic herpes simplex virus, which is based on HSV-1 with ICP0 deleted. The deletion of ICP0 were attenuated for viral growth, and impaired for viral reactivation when equivalent latent infections were established in vivo. This product can be used in oncolytic virotherapy research and further recombinant HSV construction.
Specifications | |
|---|---|
| Family | Herpesviridae |
| Species | Herpes simplex virus |
| Serotype | Herpes simplex virus 1 |
| Backbone | HSV-1 (ΔΔICP0) |
| Backbone Background | Herpes simplex virus 1 and 2 (HSV-1 and HSV-2), also known as human herpesvirus 1 and 2 (HHV-1 and HHV-2), are two members of the human Herpesviridae family, a set of viruses that produce viral infections in the majority of humans. Modified Herpes simplex virus is considered as a potential therapy for cancer and has been extensively clinically tested to assess its oncolytic ability. |
| Gene Modification | ΔΔICP0 |
| Promoter | SV40 |
| Transgene | IL-4 |
| Type of Transgene | Cytokine |
| Related Target/Protein | Interleukin 4 |
| Capsid Modification | None |
| Titer | >1*10^8 PFU |
| Related Diseases | Osteosarcoma |
Transgene | |
|---|---|
| Alternative Names | IL-4, IL4, BCGF-1, BCGF1, BSF-1, BSF1, interleukin 4 |
| Gene ID | 3565 |
Information | |
|---|---|
| Introduction | The interleukin 4 (IL4, IL-4) is a cytokine that induces differentiation of naive helper T cells (Th0 cells) to Th2 cells. Upon activation by IL-4, Th2 cells subsequently produce additional IL-4 in a positive feedback loop. The cell that initially produces IL-4, thus inducing Th2 differentiation, has not been identified, but recent studies suggest that basophils may be the effector cell. It is closely related and has functions similar to Interleukin 13. |
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