This product is a vasculostatin expressing oncolytic herpes simplex virus, which is based on HSV-1 with ICP34.5 and UNG deleted. ICP34.5 protein, is important for viral replication, viral exit from infected cells, prevention of the premature shut-off of protein synthesis in the infected host, and neurovirulence. Uracil DNA glycosylase (UNG, UDG) is the most abundant cellular enzyme encoded by the UL2 gene for removing uracil generated by hydrolytic deamination of cytosine or misincorporation of dUTP. The deletion of UDG may have contributed to lower rates of DNA repair during the passage or selection conditions. This product can be used in oncolytic virotherapy research and further recombinant HSV construction.
Specifications
Family
Herpesviridae
Species
Herpes simplex virus
Serotype
Herpes simplex virus 1
Backbone
HSV-1 (ΔICP34.5, ΔUNG)
Backbone Background
Herpes simplex virus 1 and 2 (HSV-1 and HSV-2), also known as human herpesvirus 1 and 2 (HHV-1 and HHV-2), are two members of the human Herpesviridae family, a set of viruses that produce viral infections in the majority of humans. Modified Herpes simplex virus is considered as a potential therapy for cancer and has been extensively clinically tested to assess its oncolytic ability.
Gene Modification
ΔICP34.5, ΔUNG
Promoter
IE4/5
Transgene
vasculostatin
Type of Transgene
Cytokine
Related Target/Protein
Vasculostatin
Capsid Modification
None
Titer
>1*10^8 PFU
Related Diseases
Brain cancer
Transgene
Alternative Names
vasculostatin
Information
Introduction
Vasculostatin, a proteolytic fragment of brain Angiogenesis inhibitor 1, is an antiangiogenic and antitumorigenic factor, inhibited migration of endothelial cells in vitro and dramatically reduced in vivo angiogenesis.
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Datasheet