GM-CSF-expressing Oncolytic Herpes Simplex Virus 2 (ΔICP10PK), hTERT-GM-CSF(Cat#: CyOV-0311XY)
DatasheetThis product is a GM-CSF expressing oncolytic herpes simplex virus, which is based on HSV-2 with ICP10PK deleted. The herpes simplex virus type 2 (HSV-2) protein ICP10PK has anti-apoptotic activity independent of other viral proteins that ICP10 PK-induced activation of the ERK survival pathway results in Bag-1 upregulation. The deletion of ICP10PK can enhance the oncolytic activity. This product can be used in oncolytic virotherapy research and further recombinant HSV construction.
Specifications | |
|---|---|
| Family | Herpesviridae |
| Species | Herpes simplex virus |
| Serotype | Herpes simplex virus 2 |
| Backbone | HSV-2 (ΔICP10PK) |
| Backbone Background | Herpes simplex virus 1 and 2 (HSV-1 and HSV-2), also known as human herpesvirus 1 and 2 (HHV-1 and HHV-2), are two members of the human Herpesviridae family, a set of viruses that produce viral infections in the majority of humans. Modified Herpes simplex virus is considered as a potential therapy for cancer and has been extensively clinically tested to assess its oncolytic ability. |
| Gene Modification | ΔICP10PK |
| Promoter | hTERT |
| Transgene | GM-CSF |
| Type of Transgene | Cytokine |
| Related Target/Protein | Granulocyte-macrophage colony-stimulating factor |
| Capsid Modification | None |
| Titer | >1*10^8 PFU |
| Related Diseases | Neurodegenerative diseases |
Transgene | |
|---|---|
| Alternative Names | CSF2, CSF, GMCSF, GM-CSF, colony stimulating factor 2 |
| Gene ID | 1437 |
Information | |
|---|---|
| Introduction | Granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as colony-stimulating factor 2 (CSF2), is a monomeric glycoprotein secreted by macrophages, T cells, mast cells, natural killer cells, endothelial cells and fibroblasts that functions as a cytokine. Unlike granulocyte colony-stimulating factor, which specifically promotes neutrophil proliferation and maturation, GM-CSF affects more cell types, especially macrophages and eosinophils. |
Customer Reviews and Q&As |
|---|
|
There are currently no customer reviews or questions for GM-CSF-expressing Oncolytic Herpes Simplex Virus 2 (ΔICP10PK), hTERT-GM-CSF (CyOV-0311XY). Click the button below to contact us or submit your feedback about this product. |
All products and services are for Research Use Only. Not For Clinical Use.
Other products
- luciferase-encoding Oncolytic Herpes Simplex Virus 1 (ΔICP34.5, ΔUNG), IE4/5-luciferase (CAT#: RepOV-0071XY)
- lacZ-encoding Oncolytic Herpes Simplex Virus 1 (ΔICP6, ΔΔICP34.5), SV40-lacZ (CAT#: RepOV-0106XY)
- CCL17-expressing Oncolytic Herpes Simplex Virus 2 (ΔICP10PK), CMV-CCL17 (CAT#: CyOV-0281XY)
- mCherry-encoding Oncolytic Herpes Simplex Virus 2 (ΔICP10PK), SV40-mCherry (CAT#: RepOV-0162XY)
- luciferase-encoding Oncolytic Herpes Simplex Virus 1 (ΔΔICP34.5, ΔΔICP47), SV40-luciferase (CAT#: RepOV-0119XY)
- GFP-encoding Oncolytic Herpes Simplex Virus 1 (ΔICP27), CMV-GFP (CAT#: RepOV-0003XY)
- IL-2-expressing Oncolytic Herpes Simplex Virus 1 (ΔΔICP34.5, ΔΔICP47), SV40-IL-2 (CAT#: CyOV-0279XY)
- IL-12-expressing Oncolytic Herpes Simplex Virus 1 (ΔΔICP34.5, ΔΔICP47), IE4/5-IL-12 (CAT#: CyOV-0206XY)
PRODUCTS
Online Inquiry