vasculostatin-expressing Oncolytic Herpes Simplex Virus 2 (ΔICP10PK), hTERT-vasculostatin(Cat#: CyOV-0316XY)
DatasheetThis product is a vasculostatin expressing oncolytic herpes simplex virus, which is based on HSV-2 with ICP10PK deleted. The herpes simplex virus type 2 (HSV-2) protein ICP10PK has anti-apoptotic activity independent of other viral proteins that ICP10 PK-induced activation of the ERK survival pathway results in Bag-1 upregulation. The deletion of ICP10PK can enhance the oncolytic activity. This product can be used in oncolytic virotherapy research and further recombinant HSV construction.
Specifications | |
|---|---|
| Family | Herpesviridae |
| Species | Herpes simplex virus |
| Serotype | Herpes simplex virus 2 |
| Backbone | HSV-2 (ΔICP10PK) |
| Backbone Background | Herpes simplex virus 1 and 2 (HSV-1 and HSV-2), also known as human herpesvirus 1 and 2 (HHV-1 and HHV-2), are two members of the human Herpesviridae family, a set of viruses that produce viral infections in the majority of humans. Modified Herpes simplex virus is considered as a potential therapy for cancer and has been extensively clinically tested to assess its oncolytic ability. |
| Gene Modification | ΔICP10PK |
| Promoter | hTERT |
| Transgene | vasculostatin |
| Type of Transgene | Cytokine |
| Related Target/Protein | Vasculostatin |
| Capsid Modification | None |
| Titer | >1*10^8 PFU |
| Related Diseases | Neurodegenerative diseases |
Transgene | |
|---|---|
| Alternative Names | vasculostatin |
Information | |
|---|---|
| Introduction | Vasculostatin, a proteolytic fragment of brain Angiogenesis inhibitor 1, is an antiangiogenic and antitumorigenic factor, inhibited migration of endothelial cells in vitro and dramatically reduced in vivo angiogenesis. |
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