IL-24-expressing Oncolytic Vaccinia Virus Western Reserve (ΔE3L), p7.5k-(IL-24)(Cat#: CyOV-0047WQ)
DatasheetThis product is a IL-24 expressing oncolytic vaccinia virus, which is based on VACV-WR with E3L deleted. IL-24 appears to control in cell survival and proliferation by inducing rapid activation of particular transcription factors called STAT1 and STAT3. IL-24 performs important roles in wound healing, arthritis, psoriasis and cancer. The deletion of E3L and IL-24 expressing could enhance the immune and anti-tumor activity. This product can also be used in oncolytic virotherapy research and vaccinie application.
Specifications | |
|---|---|
| Family | Poxviridae |
| Species | Vaccinia virus |
| Serotype | Western Reserve |
| Backbone | VACV-WR(ΔE3L) |
| Backbone Background | VACV-WR strain derived from Wyeth through passaging in mice and shown high tumor selectivity and strong oncolytic effect in mouse models.The engineered VACV-WR could further enhance the immune activity and the efficacy of cancer therapies. |
| Gene Modification | ΔE3L |
| Promoter | p7.5k |
| Transgene | IL-24 |
| Type of Transgene | Cytokine |
| Related Target/Protein | Interleukin 24 |
| Capsid Modification | None |
| Titer | >1*10^8 PFU |
| Related Diseases | Tumor |
Information | |
|---|---|
| Introduction | This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. |
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