hIFN-β-expressing Oncolytic Vaccinia Virus Western Reserve (ΔE3L), pSE-(hIFN-β)(Cat#: CyOV-0028WQ)
DatasheetThis product is a IFNβ encoding oncolytic vaccinia virus, which is based on VACV-WR with E3L deleted.The encoded protein is important for defense against viral infections and involved in cell differentiation and anti-tumor defenses.The deletion of E3L and IFNβ encoding could enhance the immune and anti-tumor activity. This product can also be used in oncolytic virotherapy research and vaccinie application.
Specifications | |
|---|---|
| Family | Poxviridae |
| Species | Vaccinia virus |
| Serotype | Western Reserve |
| Backbone | VACV-WR(ΔE3L) |
| Backbone Background | VACV-WR strain derived from Wyeth through passaging in mice and shown high tumor selectivity and strong oncolytic effect in mouse models.The engineered VACV-WR could further enhance the immune activity and the efficacy of cancer therapies. |
| Gene Modification | ΔE3L |
| Promoter | pSE |
| Transgene | hIFN-β |
| Type of Transgene | Cytokine |
| Related Target/Protein | Interferon beta |
| Capsid Modification | None |
| Titer | >1*10^8 PFU |
| Related Diseases | Pancreatic carcinoma |
Information | |
|---|---|
| Introduction | This gene encodes a cytokine that belongs to the interferon family of signaling proteins, which are released as part of the innate immune response to pathogens. The protein encoded by this gene belongs to the type I class of interferons, which are important for defense against viral infections. In addition, type I interferons are involved in cell differentiation and anti-tumor defenses. Following secretion in response to a pathogen, type I interferons bind a homologous receptor complex and induce transcription of genes such as those encoding inflammatory cytokines and chemokines. Overactivation of type I interferon secretion is linked to autoimmune diseases. Mice deficient for this gene display several phenotypes including defects in B cell maturation and increased susceptibility to viral infection. |
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