hEPO-expressing Oncolytic Vaccinia Virus Western Reserve (ΔE3L), pSL-hEPO(Cat#: CyOV-0025WQ)
DatasheetThis product is a EPO encoding oncolytic vaccinia virus, which is based on VACV-WR with E3L deleted.The encoded protein binds to the erythropoietin receptor to promote red blood cell production, or erythropoiesis, in the bone marrow and have been used in the treatment of anemia and to enhance the efficacy of cancer therapies. This product can also be used in oncolytic virotherapy research and vaccinie application.
Specifications | |
|---|---|
| Family | Poxviridae |
| Species | Vaccinia virus |
| Serotype | Western Reserve |
| Backbone | VACV-WR(ΔE3L) |
| Backbone Background | VACV-WR strain derived from Wyeth through passaging in mice and shown high tumor selectivity and strong oncolytic effect in mouse models.The engineered VACV-WR could further enhance the immune activity and the efficacy of cancer therapies. |
| Gene Modification | ΔE3L |
| Promoter | pSL |
| Transgene | hEPO |
| Type of Transgene | Cytokine |
| Related Target/Protein | Human erythropoietin |
| Capsid Modification | None |
| Titer | >1*10^8 PFU |
| Related Diseases | Tumor |
Information | |
|---|---|
| Introduction | This gene encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The encoded protein is mainly synthesized in the kidney, secreted into the blood plasma, and binds to the erythropoietin receptor to promote red blood cell production, or erythropoiesis, in the bone marrow. Expression of this gene is upregulated under hypoxic conditions, in turn leading to increased erythropoiesis and enhanced oxygen-carrying capacity of the blood. Expression of this gene has also been observed in brain and in the eye, and elevated expression levels have been observed in diabetic retinopathy and ocular hypertension. Recombinant forms of the encoded protein exhibit neuroprotective activity against a variety of potential brain injuries, as well as antiapoptotic functions in several tissue types, and have been used in the treatment of anemia and to enhance the efficacy of cancer therapies. |
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