IL-7-expressing Oncolytic Vaccinia Virus Western Reserve (ΔK3L), pSE-(IL-7)(Cat#: CyOV-0133WQ)
DatasheetThis product is a IL7 expressing oncolytic vaccinia virus, which is based on VACV-WR with K3L deleted. IL-7 stimulates the differentiation of multipotent (pluripotent) hematopoietic stem cells into lymphoid progenitor cells. IL-7 is also important for B and T cell development. The deletion of K3L and IL6 expressing could enhance the immune activity. This product can also be used in oncolytic virotherapy research and vaccinie application.
Specifications | |
|---|---|
| Family | Poxviridae |
| Species | Vaccinia virus |
| Serotype | Western Reserve |
| Backbone | VACV-WR(ΔK3L) |
| Backbone Background | VACV-WR strain derived from Wyeth through passaging in mice and shown high tumor selectivity and strong oncolytic effect in mouse models.The engineered VACV-WR could further enhance the immune activity and the efficacy of cancer therapies. |
| Gene Modification | ΔK3L |
| Promoter | pSE |
| Transgene | IL-7 |
| Type of Transgene | Cytokine |
| Related Target/Protein | Interleukin 7 |
| Capsid Modification | None |
| Titer | >1*10^8 PFU |
| Related Diseases | Lung carcinoma |
Information | |
|---|---|
| Introduction | The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their presence in normal tissues has not been confirmed. |
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