CXCL10-expressing Oncolytic Vaccinia Virus Western Reserve (ΔK3L), pSE/L-CXCL10(Cat#: CyOV-0084WQ)
DatasheetThis product is a CXCL10 expressing oncolytic vaccinia virus, which is based on VACV-WR with K3L deleted. Binding of CXCL10 to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. The deletion of K3L and CXCL10 expression could enhance the immune activity. This product can be used in oncolytic virotherapy research and vaccinie application.
Specifications | |
|---|---|
| Family | Poxviridae |
| Species | Vaccinia virus |
| Serotype | Western Reserve |
| Backbone | VACV-WR(ΔK3L) |
| Backbone Background | VACV-WR strain derived from Wyeth through passaging in mice and shown high tumor selectivity and strong oncolytic effect in mouse models.The engineered VACV-WR could further enhance the immune activity and the efficacy of cancer therapies. |
| Gene Modification | ΔK3L |
| Promoter | pSE/L |
| Transgene | CXCL10 |
| Type of Transgene | Cytokine |
| Related Target/Protein | C-X-C motif chemokine ligand 10 |
| Capsid Modification | None |
| Titer | >1*10^8 PFU |
| Related Diseases | Mammary tumor |
Transgene | |
|---|---|
| Alternative Names | C7; IFI10; INP10; IP-10; crg-2; mob-1; SCYB10; gIP-10 |
| Gene ID | 3630 |
| UniProt ID | P02781 |
Information | |
|---|---|
| Introduction | This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. |
Customer Reviews and Q&As |
|---|
|
There are currently no customer reviews or questions for CXCL10-expressing Oncolytic Vaccinia Virus Western Reserve (ΔK3L), pSE/L-CXCL10 (CyOV-0084WQ). Click the button below to contact us or submit your feedback about this product. |
All products and services are for Research Use Only. Not For Clinical Use.
Other products
- TNF-α-expressing Oncolytic Vaccinia Virus Western Reserve (ΔE3L), pSE/L-(TNF-α) (CAT#: CyOV-0074WQ)
- mCherry-encoding Oncolytic Vaccinia Virus Western Reserve (ΔE3L,ΔK3), pSE/L-(mCherry) (CAT#: RepOV-0084WQ)
- 4-1BBL-expressing Oncolytic Vaccinia Virus Western Reserve (ΔE3L), p11k-(4-1BBL) (CAT#: CyOV-0001WQ)
- IL-24-expressing Oncolytic Vaccinia Virus Western Reserve (ΔK3L), p7.5k-(IL-24) (CAT#: CyOV-0122WQ)
- mCherry-encoding Oncolytic Vaccinia Virus Western Reserve (ΔE3L), p7.5k-(mCherry) (CAT#: RepOV-0012WQ)
- lacZ-encoding Oncolytic Vaccinia Virus Western Reserve (ΔE3L,ΔK3), p7.5k-(lacZ) (CAT#: RepOV-0070WQ)
- CXCL13-expressing Oncolytic Vaccinia Virus Western Reserve (ΔK3L), pSE/L-CXCL13 (CAT#: CyOV-0089WQ)
- EGFP-encoding Oncolytic Vaccinia Virus Western Reserve (ΔE3L), pSE-(EGFP) (CAT#: RepOV-0014WQ)
PRODUCTS
Online Inquiry