Dsred-encoding Oncolytic Herpes Simplex Virus 1 (ΔICP27), hTERT-Dsred(Cat#: RepOV-0031XY)

This product is a Dsred encoding oncolytic herpes simplex virus, which is based on HSV-1 with ICP27 deleted. ICP27 is highly cytotoxic probably due to its secondary role of preventing the splicing of pre-mRNAs in favour of translation from the mainly unspliced hepes RNAs. Deletion of ICP27 might produce a safer and less cytotoxic system when combined with other oncolytic-rendered modifications. This product can be used in oncolytic virotherapy research and further recombinant HSV construction.

Specifications

Family Herpesviridae
Species Herpes simplex virus
Serotype Herpes simplex virus 1
Backbone HSV-1 (ΔICP27)
Backbone Background Herpes simplex virus 1 and 2 (HSV-1 and HSV-2), also known as human herpesvirus 1 and 2 (HHV-1 and HHV-2), are two members of the human Herpesviridae family, a set of viruses that produce viral infections in the majority of humans. Modified Herpes simplex virus is considered as a potential therapy for cancer and has been extensively clinically tested to assess its oncolytic ability.
Gene Modification ΔICP27
Promoter hTERT
Transgene Dsred
Type of Transgene Reporter gene
Related Target/Protein Discosoma red fluorescent protein
Capsid Modification None
Titer >1*10^8 PFU
Related Diseases Tumor

Transgene

Alternative Names DsRed, Discosoma red fluorescent protein
UniProt ID Q2WG74

Information

Introduction Red fluorescent protein (RFP) is a fluorophore that fluoresces red-orange when excited. Several variants have been developed using directed mutagenesis. The original was isolated from Discosoma, and named DsRed. Others are now available that fluoresce orange, red, and far-red.RFP is approximately 25.9 kDa. The excitation maximum is 558 nm, and the emission maximum is 583 nm.

Customer Reviews and Q&As

There are currently no customer reviews or questions for Dsred-encoding Oncolytic Herpes Simplex Virus 1 (ΔICP27), hTERT-Dsred (RepOV-0031XY). Click the button below to contact us or submit your feedback about this product.

All products and services are for Research Use Only. Not For Clinical Use.

Other products

PRODUCTS

Online Inquiry