Dsred-encoding Oncolytic Herpes Simplex Virus 2 (ΔICP10PK), hTERT-Dsred(Cat#: RepOV-0133XY)
DatasheetThis product is a Dsred encoding oncolytic herpes simplex virus, which is based on HSV-2 with ICP10PK deleted. The herpes simplex virus type 2 (HSV-2) protein ICP10PK has anti-apoptotic activity independent of other viral proteins that ICP10 PK-induced activation of the ERK survival pathway results in Bag-1 upregulation. The deletion of ICP10PK can enhance the oncolytic activity. This product can be used in oncolytic virotherapy research and further recombinant HSV construction.
Specifications | |
|---|---|
| Family | Herpesviridae |
| Species | Herpes simplex virus |
| Serotype | Herpes simplex virus 2 |
| Backbone | HSV-2 (ΔICP10PK) |
| Backbone Background | Herpes simplex virus 1 and 2 (HSV-1 and HSV-2), also known as human herpesvirus 1 and 2 (HHV-1 and HHV-2), are two members of the human Herpesviridae family, a set of viruses that produce viral infections in the majority of humans. Modified Herpes simplex virus is considered as a potential therapy for cancer and has been extensively clinically tested to assess its oncolytic ability. |
| Gene Modification | ΔICP10PK |
| Promoter | hTERT |
| Transgene | Dsred |
| Type of Transgene | Reporter gene |
| Related Target/Protein | Discosoma red fluorescent protein |
| Capsid Modification | None |
| Titer | >1*10^8 PFU |
| Related Diseases | Neurodegenerative diseases |
Transgene | |
|---|---|
| Alternative Names | DsRed, Discosoma red fluorescent protein |
| UniProt ID | Q2WG74 |
Information | |
|---|---|
| Introduction | Red fluorescent protein (RFP) is a fluorophore that fluoresces red-orange when excited. Several variants have been developed using directed mutagenesis. The original was isolated from Discosoma, and named DsRed. Others are now available that fluoresce orange, red, and far-red.RFP is approximately 25.9 kDa. The excitation maximum is 558 nm, and the emission maximum is 583 nm. |
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