luciferase-encoding Oncolytic Herpes Simplex Virus 2 (ΔRL), SV40-luciferase(Cat#: RepOV-0167XY)
DatasheetThis product is a luciferase encoding oncolytic herpes simplex virus, which is based on HSV-2 with RL deleted. The deletion lies entirely within the sequences deleted in JH2604 in which only 850 bp are removed from the RL. This product can be used in oncolytic virotherapy research and further recombinant HSV construction.
Specifications | |
|---|---|
| Family | Herpesviridae |
| Species | Herpes simplex virus |
| Serotype | Herpes simplex virus 2 |
| Backbone | HSV-2 (ΔRL) |
| Backbone Background | Herpes simplex virus 1 and 2 (HSV-1 and HSV-2), also known as human herpesvirus 1 and 2 (HHV-1 and HHV-2), are two members of the human Herpesviridae family, a set of viruses that produce viral infections in the majority of humans. Modified Herpes simplex virus is considered as a potential therapy for cancer and has been extensively clinically tested to assess its oncolytic ability. |
| Gene Modification | ΔRL |
| Promoter | SV40 |
| Transgene | luciferase |
| Type of Transgene | Reporter gene |
| Related Target/Protein | Luciferase |
| Capsid Modification | None |
| Titer | >1*10^8 PFU |
| Related Diseases | Tumor |
Transgene | |
|---|---|
| Alternative Names | luciferase, Fluc |
Information | |
|---|---|
| Introduction | Luciferase is a generic term for the class of oxidative enzymes that produce bioluminescence, and is usually distinguished from a photoprotein. Luciferases are widely used in biotechnology, for microscopy and as reporter genes, for many of the same applications as fluorescent proteins. However, unlike fluorescent proteins, luciferases do not require an external light source, but do require addition of luciferin, the consumable substrate. |
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