mCherry-encoding Oncolytic Vaccinia Virus Western Reserve (ΔK3L), p11k-(mCherry)(Cat#: RepOV-0036WQ)
DatasheetThis product is a mCherry encoding oncolytic vaccinia virus, which is based on VACV-WR with K3L deleted. Binding of CXCL10 to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. The deletion of K3L and CXCL10 expression could enhance the immune activity. This product can be used in oncolytic virotherapy research and vaccinie application.
Specifications | |
|---|---|
| Family | Poxviridae |
| Species | Vaccinia virus |
| Serotype | Western Reserve |
| Backbone | VACV-WR(ΔK3L) |
| Backbone Background | VACV-WR strain derived from Wyeth through passaging in mice and shown high tumor selectivity and strong oncolytic effect in mouse models.The engineered VACV-WR could further enhance the immune activity and the efficacy of cancer therapies. |
| Gene Modification | ΔK3L |
| Promoter | p11k |
| Transgene | mCherry |
| Type of Transgene | Reporter gene |
| Related Target/Protein | mCherry Fluorescence Protein |
| Capsid Modification | None |
| Titer | >1*10^8 PFU |
| Related Diseases | Breast cancer, Prostate cancer, Colon cancer, Cancer vaccine |
Transgene | |
|---|---|
| Alternative Names | mCherry |
| UniProt ID | X5DSL3 |
Information | |
|---|---|
| Introduction | mCherry is a member of the mFruits family of monomeric red fluorescent proteins (mRFPs). As a RFP, mCherry was derived from DsRed of Discosoma sea anemones. mCherry absorbs light between 540-590 nm and emits light in the range of 550-650 nm. mCherry belongs to the group of fluorescent protein chromophores used as vital instruments to visualize genes and analyze their functions in experiments. Genome editing has been improved greatly through the precise insertion of these fluorescent protein tags into the genetic material of many diverse organisms. Most comparisons between the brightness and photostability of different fluorescent proteins have been made in vitro, removed from biological variables that affect protein performance in cells or organisms. It is hard to perfectly simulate cellular environments in vitro, and the difference in environment could have an effect on the brightness and photostability. |
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