17-GMB-APA-GA (CAT#: ADC-P-094)

ADCs Toxins, 17-GMB-APA-GA is an Geldanamycin analog equipped with linker for coupling to proteins or antibodies for the preparation of immunoconjugates, for example. This geldanamycin immunoconjugate induces less systemic toxicity than geldanamycin by being selectively delivered into malignant cells. This linker chain is just an example. We can also install other types of simpler side chains for example a chain with a free NH2 at its terminus. Reference: 1. R. Mandler et al. Cancer Res. 2004 64:1460; 2. R. Mandler et al. Bioconj. Chem. 2002 13:786; 3. R. Mandler et al. J. Natl. Cancer Inst. 2000 92:1573

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ADCs Toxins, 17-GMB-APA-GA is an Geldanamycin analog equipped with linker for coupling to proteins or antibodies for the preparation of immunoconjugates, for example. This geldanamycin immunoconjugate induces less systemic toxicity than geldanamycin by being selectively delivered into malignant cells. This linker chain is just an example. We can also install other types of simpler side chains for example a chain with a free NH2 at its terminus. Reference: 1. R. Mandler et al. Cancer Res. 2004 64:1460; 2. R. Mandler et al. Bioconj. Chem. 2002 13:786; 3. R. Mandler et al. J. Natl. Cancer Inst. 2000 92:1573