Cryptophycin (CAT#: ADC-P-035)

ADCs Toxins, Cryptophycins are potent microtubule inhibitors, with a mechanism of action similar to that of paclitaxel and vinca alkaloids. Treatment of cells with cryptophycins depletes microtubules through interaction with tubulin, thereby preventing cell division. Cryptophycins are capable of inducing apoptosis, possibly through other mechanisms in addition to that mediated by microtubule inhibition.

Product Information

CAS NO
124689-65-2

Description
ADCs Toxins, Cryptophycins are potent microtubule inhibitors, with a mechanism of action similar to that of paclitaxel and vinca alkaloids. Treatment of cells with cryptophycins depletes microtubules through interaction with tubulin, thereby preventing cell division. Cryptophycins are capable of inducing apoptosis, possibly through other mechanisms in addition to that mediated by microtubule inhibition.

Classification
Microtubule Inhibitors

Molecular Weight
669.2

Purity
95%

For Research Use Only. NOT FOR CLINICAL USE.

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Excellent

Using Cryptophycin from Creative Biolabs significantly enhanced our ADC research. Its potent microtubule inhibition is comparable to paclitaxel, effectively preventing cell division and inducing apoptosis. We observed remarkable consistency in our results, making it a reliable choice for our experiments.

Excellent

Cryptophycin's ability to deplete microtubules and induce apoptosis has been invaluable in our studies. The compound's action mechanism aligns well with our experimental needs, and Creative Biolabs provided excellent support throughout our research process.

Excellent

We chose Cryptophycin for its strong microtubule inhibition, and it did not disappoint. The results were consistent, and the apoptosis induction was evident across multiple cell lines. Creative Biolabs' expertise is reflected in this top-tier product.

Excellent

Cryptophycin has proven to be a potent tool in our ADC development. Its similarity to paclitaxel and vinca alkaloids in action made it an ideal choice, yielding reliable results in cell division inhibition. A great product from Creative Biolabs.

Excellent

Our team has seen excellent results with Cryptophycin, particularly in its ability to prevent cell division through tubulin interaction. The consistency and reliability of the product from Creative Biolabs have made it a staple in our lab.

Q: 1: What is the primary mechanism of action of Cryptophycin in ADCs?
A: Cryptophycin functions as a potent microtubule inhibitor, disrupting the microtubule network within cells. This disruption occurs through its interaction with tubulin, leading to the depletion of microtubules. As a result, cell division is effectively halted, contributing to its utility in ADCs as a means of inducing cell death.
Q: 2: How does Cryptophycin compare to other microtubule inhibitors like paclitaxel and vinca alkaloids?
A: Cryptophycin shares a similar mechanism of action with paclitaxel and vinca alkaloids, as all three compounds inhibit microtubules. However, Cryptophycin's distinct structure and interaction with tubulin may offer unique advantages in certain therapeutic applications, particularly within ADCs.
Q: 3: What effects does Cryptophycin have on cell division?
A: Cryptophycin prevents cell division by depleting microtubules, a critical component of the cell's cytoskeleton. Without a functional microtubule network, cells cannot properly divide, leading to the cessation of cell proliferation and ultimately, cell death.
Q: 4: What are the potential applications of Cryptophycin in cancer therapy?
A: Cryptophycin is primarily used in ADCs to target and kill cancer cells by inhibiting microtubules and inducing apoptosis. Its potent action against dividing cells makes it a promising candidate for treating various types of cancer, especially those resistant to other microtubule inhibitors.
Q: 5: Is Cryptophycin effective against paclitaxel-resistant cancer cells?
A: Is Cryptophycin effective against paclitaxel-resistant cancer cells?
Q: 6: How does Cryptophycin-induced microtubule depletion lead to cell death?
A: The depletion of microtubules caused by Cryptophycin disrupts essential cellular functions, including the ability to maintain cell shape, transport organelles, and divide. This disruption ultimately triggers cell death, making Cryptophycin an effective component of ADCs.

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