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- Anti-Robo4-SPDP-NCS ADC
Anti-Robo4-SPDP-NCS ADC (CAT#: ADC-W-583)
This ADC product is comprised of an anti-ROBO4 monoclonal antibody conjugated via a SPDP linker to NCS. The NCS is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis.
- ADC Target
- ADC Antibody
- ADC Linker
- ADC payload drug
- Name
- ROBO4
- Alternative Names
- ROBO4; roundabout, axon guidance receptor, homolog 4 (Drosophila); MRB; ECSM4; roundabout homolog 4; roundabout homolog 4, magic roundabout;
- Target Entrez Gene ID
- 54538
- Target UniProt ID
- B4DYV8
- Overview
- ROBO4 (Roundabout, Axon Guidance Receptor, Homolog 4 (Drosophila)) is a Protein Coding gene. Among its related pathways are Development Slit-Robo signaling. GO annotations related to this gene include receptor activity.
- Overview
- Anti-ROBO4 Antibody
- Species Reactivity
- Human
- Name
- SPDP(N-succinimidyl 3-[2-pyridyldithio]-propionate)
- Description
- Disulfide Linkers, are extensively exploited as a chemically labile linkage. Since the release of disulfide-linked drugs requires a cytoplasmic thiol cofactor, such as glutathione (GSH). Disulfides maintain stable at physiological pH and only when ADCs are internalized inside cells, the cytosol provides reducing environment including intracellular enzyme protein disulfide isomerase, or similar enzymes, drugs can be released.
- Name
- NCS
- Description
- Neocarzinostatin (NCS) is a macromolecular chromoprotein enediyne antitumor antibiotic secreted by Streptomyces macromomyceticus. It is a product naturally found as a complex of an enediyne chromophore and a 10-kDa protein and it can induce both single-and double-strand breaks in DNA.
For Research Use Only. NOT FOR CLINICAL USE.
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Quick Links
Other Products
Same Target
Same Linker
Same Payload
| CAT# | Product Name | Linker | Payload |
| ADC-W-213 | Anti-Robo4-MCC-DM1 ADC | MCC (Maleimidomethyl cyclohexane-1-carboxylate) | DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) |
| ADC-W-215 | Anti-Robo4-mPEO-DM1 ADC | Mpeo (methoxy-polyethylene oxide) | DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) |
| ADC-W-214 | Anti-Robo4-SPDB-DM4 ADC | SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) | DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine) |
| CAT# | Product Name | Linker | Payload |
| ADC-W-585 | Anti-FLAG-SPDP-NCS ADC | SPDP(N-succinimidyl 3-[2-pyridyldithio]-propionate) | NCS |
| ADC-W-584 | Anti-KDR-SPDP-NCS ADC | SPDP(N-succinimidyl 3-[2-pyridyldithio]-propionate) | NCS |
| CAT# | Product Name | Linker | Payload |
| ADC-W-584 | Anti-KDR-SPDP-NCS ADC | SPDP(N-succinimidyl 3-[2-pyridyldithio]-propionate) | NCS |
| ADC-W-585 | Anti-FLAG-SPDP-NCS ADC | SPDP(N-succinimidyl 3-[2-pyridyldithio]-propionate) | NCS |
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