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- Anti-TACSTD2 (clone C16)-PEG6-Aur3377 ADC
Anti-TACSTD2 (clone C16)-PEG6-Aur3377 ADC (CAT#: ADC-W-539)
This ADC product is comprised of an anti-TACSTD2 monoclonal antibody (clone C16) conjugated via a PEG6 linker to Aur3377. The Aur3377 is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, Aur3377 binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death.
- Product Information
- ADC Target
- ADC Antibody
- ADC Linker
- ADC payload drug
- Antibody clone #
- C16
- Name
- TACSTD2
- Alternative Names
- TACSTD2; tumor-associated calcium signal transducer 2; EGP1; GP50; M1S1; EGP-1; TROP2; GA7331; GA733-1; epithelial glycoprotein-1; cell surface glycoprotein TROP2; cell surface glycoprotein Trop-2; pancreatic carcinoma marker protein GA7331; pancreatic ca
- Target Entrez Gene ID
- 4070
- Target UniProt ID
- P09758
- Overview
- This intronless gene encodes a carcinoma-associated antigen. This antigen is a cell surface receptor that transduces calcium signals. Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy.
- Overview
- Anti-TACSTD2 Antibody, clone # C16
- Clone #
- C16
- Species Reactivity
- Human
- Name
- Amino-PEG6-based linker
- Name
- Aur3377
- Description
- Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
For Research Use Only. NOT FOR CLINICAL USE.
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Other Products
Same Target
Same Linker
| CAT# | Product Name | Linker | Payload |
| ADC-W-290 | Anti-TACSTD2 (clone 7E6)-AcLys-VC-PABC-MMAD ADC | AcLys-VC- PABC (Acetyl-lysine-valine-citrulline-p-aminobenzyloxycarbonyl) | MMAD (monomethyl auristatin D) |
| ADC-W-292 | Anti-TACSTD2 (clone 7E6)-PEG6-MMAD ADC | PEG6 ((Propylene Glycol)-6-propionyl) | MMAD (monomethyl auristatin D) |
| ADC-W-563 | Anti-TACSTD2 (clone C16)-VC-PABC-Aur0101 ADC | VC-PABC (valine-citrulline-p-aminobenzylcarbamate) | Aur0101 |
| ADC-W-568 | Anti-TACSTD2 (clone C16)-VC-MMAD ADC | VC (valine-citrulline) | MMAD (monomethyl auristatin D) |
| ADC-W-570 | Anti-TACSTD2 (clone C16)-Mc-VC-MMAD ADC | Mc-VC (maleimidocaproyl-valine-alanine) | MMAD (monomethyl auristatin D) |
| CAT# | Product Name | Linker | Payload |
| ADC-W-538 | Anti-TACSTD2 (clone C16)-PEG6-MMAD ADC | Amino-PEG6-based linker | MMAD (monomethyl auristatin D) |
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