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- Anti-ERBB2 (Trastuzumab) Fab -Porphyrin ADC
Anti-ERBB2 (Trastuzumab) Fab -Porphyrin ADC (CAT#: ADC-W-420)
This ADC product is comprised of a Fab fragment of anti-ERBB2 monoclonal antibody (Trastuzumab) conjugated via a linker to a Porphyrin.
- ADC Target
- ADC Antibody
- ADC Linker
- ADC payload drug
- Name
- ERBB2
- Alternative Names
- ERBB2; erb-b2 receptor tyrosine kinase 2; NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu; receptor tyrosine-protein kinase erbB-2; herstatin; p185erbB2; proto-oncogene Neu; c-erb B2/neu protein; proto-oncogene c-ErbB-2; metastatic lymph node gene 1
- Target Entrez Gene ID
- 2064
- Target UniProt ID
- P04626
- Overview
- This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
- Overview
- Humanized Anti-ERBB2 Antibody, Trastuzumab FabTRA
- Generic name
- Trastuzumab
- Species Reactivity
- Human
- Name
- PEG
- Name
- Porphyrin
For Research Use Only. NOT FOR CLINICAL USE.
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Other Products
Same Target
Same Payload
| CAT# | Product Name | Linker | Payload |
| ADC-W-2595 | Anti-ERBB2 (Trastuzumab)-SPDB-DM4 ADC | SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) | DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine) |
| ADC-W-1110 | Anti-ERBB2 (Margetuximab)-MC-Vc-PAB-SN38 ADC | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | SN-38 (7-ethyl-10-hydroxycamptothecin) |
| ADC-W-514 | Anti-ERBB2 (Trastuzumab)-VC-DUBA ADC | VC (valine-citrulline) | seco-DUBA (DUocarmycin hydroxyBenzamide Azaindole) |
| ADC-W-1111 | Anti-ERBB2 (Margetuximab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC | MC-Vc-PAB-DMEA-(PEG2) | duocarmycin SA |
| ADC-W-572 | Anti-ERBB2 (Trastuzumab-Fab)-SPP-DM1 ADC | SPP (N-succinimidyl-4-(2-pyridyldithio)pentanoate) | DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) |
| CAT# | Product Name | Linker | Payload |
| ADC-W-421 | Anti-ERBB2 (Trastuzumab) Fab -PEG-porphyrin ADC | porphyrin |
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