- Home
- Products
- Customized ADCs
- SLC3A2
- Anti-SLC3A2 (clone IGNX)-DBM-MMAF ADC
Anti-SLC3A2 (clone IGNX)-DBM-MMAF ADC (CAT#: ADC-W-548)
This ADC product is comprised of an anti-SLC3A2 monoclonal antibody (clone IGNX) conjugated via a DBM linker to MMAF. The MMAF is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, MMAF binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death.
- Product Information
- ADC Target
- ADC Antibody
- ADC Linker
- ADC payload drug
- Antibody clone #
- IGNX
- Name
- SLC3A2
- Alternative Names
- SLC3A2; solute carrier family 3 (amino acid transporter heavy chain), member 2; 4F2; CD98; MDU1; 4F2HC; 4T2HC; NACAE; CD98HC; 4F2 cell-surface antigen heavy chain; CD98 heavy chain; monoclonal antibody 44D7; solute carrier family 3 member 2; lymphocyte ac
- Target Entrez Gene ID
- 6520
- Target UniProt ID
- J3KPF3
- Overview
- This gene is a member of the solute carrier family and encodes a cell surface, transmembrane protein. The protein exists as the heavy chain of a heterodimer, covalently bound through di-sulfide bonds to one of several possible light chains. The encoded transporter plays a role in regulation of intracellular calcium levels and transports L-type amino acids. Alternatively spliced transcript variants, encoding different isoforms, have been characterized.
- Overview
- Anti-SLC3A2 Antibody, IGNX
- Clone #
- IGNX
- Species Reactivity
- Human
- Name
- DBM(dibromomaleimide)
- Name
- MMAF (Monomethyl auristatin F)
- Description
- Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
For Research Use Only. NOT FOR CLINICAL USE.
Related Products
- Anti-CD79b (clone hu2F2.D7)-Mc-vc-PABC-MMAE ADC (CAT#: ADC-W-172)
- Anti-MUC1 (clone hPAM4)-CL2A-SN-38 ADC (CAT#: ADC-W-594)
- Anti-IAV HA (Diridavumab(CR6261))-MC-Vc-PAB-SN38 ADC (CAT#: ADC-W-2070)
- Anti-TAG-72 (Satumomab Pendetide)-MC-Vc-PAB-MMAE ADC (CAT#: ADC-W-2159)
- Anti-CD79b (clone huMA79b.v18)-BMPEO-DM1 ADC (CAT#: ADC-W-025)
- Anti-TNFRSF17 (clone CA8 J6M1)-Mc-MMAF ADC (CAT#: ADC-W-279)
- Anti-SLC34A2 (Lifastuzumab )-MC-Vc-PAB-SN38 ADC (CAT#: ADC-W-2575)
- Anti-ERBB2 (cFRP5)-MCC-DM1 ADC (CAT#: ADC-W-511)
- Anti-TACSTD2 (clone C16)-VC-PABC-Aur0101 ADC (CAT#: ADC-W-563)
- Anti-MS4A1 (Technetium (99mTc) nofetumomab merpentan)-MC-Vc-PAB-SN38 ADC (CAT#: ADC-W-1590)
Published Data
+ Submit Publications
Scientific Resources
Customer Reviews and FAQs
There are currently no Customer reviews or questions for ADC-W-548. Click the button above to contact us or submit your feedback about this product.
Quick Links
Other Products
Same Target
Same Linker
Same Payload
| CAT# | Product Name | Linker | Payload |
| ADC-W-550 | Anti-SLC3A2 (clone IGNX)-Mc-MMAF ADC | Mc (maleimidocaproyl) | MMAF (Monomethyl auristatin F) |
| CAT# | Product Name | Linker | Payload |
| ADC-W-547 | Anti-ERBB2 (Trastuzumab)-DBM-MMAF ADC | DBM(dibromomaleimide) | MMAF (Monomethyl auristatin F) |
| CAT# | Product Name | Linker | Payload |
| ADC-W-515 | Anti-EGFR (ABT-806)-Mc-MMAF ADC | Mc (maleimidocaproyl) | MMAF (Monomethyl auristatin F) |
| ADC-AA-009 | anti-HIgG(Fc)Fab-N-MMAF ADC | Noncleavable linkers | MMAF (Monomethyl auristatin F) |
| ADC-W-493 | Anti-CD19 (clone huB4)-Mc-MMAF ADC | Mc (maleimidocaproyl) | MMAF (Monomethyl auristatin F) |
| ADC-AA-028 | anti-MIgG(Fc)Fab-C-MMAF ADC | Cleavable linkers | MMAF (Monomethyl auristatin F) |
| ADC-W-604 | Anti-FUT3 (clone BR96)-Mc-VC-PABC-MMAF ADC | MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | MMAF (Monomethyl auristatin F) |
Online Inquiry
Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.
