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Seco-Duocarmycin SA

Seco-Duocarmycin SA (CAT#: ADC-P-149)

ADCs cytotoxin, Seco-Duocarmycin SA is a highly potent DNA alkylator, and is used as an ADC cytotoxin.

Product Information

CAS NO
144667-38-9

Description
ADCs cytotoxin, Seco-Duocarmycin SA is a highly potent DNA alkylator, and is used as an ADC cytotoxin.

Classification
DNA Inhibitors

Molecular Weight
513.93

Purity
95%

For Research Use Only. NOT FOR CLINICAL USE.

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Customer Reviews FAQ

Excellent

Seco-Duocarmycin SA from Creative Biolabs has been an exceptional compound for my DNA alkylation studies. Its potency in targeting DNA in cancer cells provided robust data for my therapeutic research.

Excellent

I utilized Seco-Duocarmycin SA in drug mechanism studies, and it demonstrated significant cytotoxicity, enabling me to observe its potential in targeting specific tumor cell populations.

Excellent

In my cellular toxicity assays, Seco-Duocarmycin SA showed remarkable results, offering insights into its role as a potent cytotoxic agent against a variety of cancer cell lines.

Excellent

In my ADC research, Seco-Duocarmycin SA demonstrated great potential as a payload. Its high potency and targeted action were instrumental in enhancing the overall efficacy of the conjugates tested.

Excellent

This compound was particularly effective in inducing cell death in my research on aggressive tumor models. Seco-Duocarmycin SA allowed for deeper understanding of DNA damage-induced apoptosis in cancer cells.

Q: 1: What is Seco-Duocarmycin SA, and what is its primary use?
A: Seco-Duocarmycin SA is a potent DNA alkylating agent used in ADC development. It selectively binds and damages DNA in cancer cells, leading to cell death.
Q: 2: What types of cancer can Seco-Duocarmycin SA-based ADCs target?
A: Seco-Duocarmycin SA-based ADCs can target various solid tumors and hematological cancers by exploiting the drug's potent DNA-damaging mechanism, leading to selective cancer cell destruction.
Q: 3: What is the mechanism of action for Seco-Duocarmycin SA?
A: Seco-Duocarmycin SA binds to the minor groove of DNA and alkylates adenine residues, leading to irreversible DNA damage and apoptosis in cancer cells.
Q: 4: How is Seco-Duocarmycin SA activated in ADCs?
A: Seco-Duocarmycin SA is inactive in its conjugated form. It is activated upon release in the tumor environment, ensuring selective DNA alkylation and minimal systemic toxicity.
Q: 5: What analytical methods confirm Seco-Duocarmycin SA conjugation in ADCs?
A: Techniques like HPLC, mass spectrometry, and SDS-PAGE are used to confirm successful conjugation of Seco-Duocarmycin SA to antibodies, ensuring its proper attachment and functionality. Creative Biolabs provides custom ADC development services using Seco-Duocarmycin SA, enabling the creation of highly potent, targeted therapies for specific cancer research applications.

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