Lactacystin (CAT#: ADC-P-106)

ADCs Toxins, Lactacystin is a cell-permeable, potent and selective proteasome inhibitor. A Streptomyces metabolite that is thought to bind irreversibly to the active site N-terminal threonine residue of the catalytic β-subunit of the 20S proteasome, thereby inhibiting its chymotrypsin and trypsin-like activities. Lactacystin induces neurite outgrowth in Neuro 2a neuroblastoma cells and has been reported to induce apoptosis in human monoblast U937 cells.

Product Information

CAS NO
133343-34-7

Description
ADCs Toxins, Lactacystin is a cell-permeable, potent and selective proteasome inhibitor. A Streptomyces metabolite that is thought to bind irreversibly to the active site N-terminal threonine residue of the catalytic β-subunit of the 20S proteasome, thereby inhibiting its chymotrypsin and trypsin-like activities. Lactacystin induces neurite outgrowth in Neuro 2a neuroblastoma cells and has been reported to induce apoptosis in human monoblast U937 cells.

Classification
Others

Molecular Weight
376.43

Purity
95%

For Research Use Only. NOT FOR CLINICAL USE.

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Customer Reviews FAQ

Excellent

Lactacystin proved to be an essential tool in our neuroblastoma research. It effectively induced neurite outgrowth in Neuro 2a cells, offering valuable insights into neurodegenerative disease models.

Excellent

I used Lactacystin in ADC research, and it performed well as a proteasome inhibitor. Its ability to block proteasomal activity enhanced the cytotoxic effects of our ADCs on targeted cells.

Excellent

Lactacystin significantly inhibited the proteasome's chymotrypsin and trypsin-like activities in my assays, leading to reliable induction of apoptosis in U937 cells. A great addition to our lab's tools.

Excellent

In ADC development, Lactacystin has proven highly effective. Its proteasome inhibition mechanism synergized well with the payloads in our targeted therapy experiments, providing strong therapeutic effects.

Excellent

I applied Lactacystin to human U937 monoblast cells, and it consistently induced apoptosis. This product is highly effective for research focused on programmed cell death mechanisms.

Q: 1: What is Lactacystin, and how is it used in research?
A: Lactacystin is a specific proteasome inhibitor that blocks the proteasomal degradation of proteins. It is used to study protein turnover, cell cycle regulation, and apoptosis in various biological systems, including cancer research.
Q: 2: Can Lactacystin be used in ADC development?
A: While primarily used for proteasome inhibition studies, Lactacystin may also be explored as a potential payload in ADCs that target cancer cells dependent on proteasome activity for survival and proliferation.
Q: 3: What are the primary research applications of Lactacystin?
A: Lactacystin is used in cancer research, neurodegenerative disease studies, and investigations into cellular stress responses. Its ability to inhibit the proteasome makes it valuable in understanding protein homeostasis.
Q: 4: Is Lactacystin suitable for use in in vivo studies?
A: Lactacystin can be used in in vivo models, but its bioavailability and stability must be carefully evaluated. It is often administered to study the effects of proteasome inhibition in animal models of cancer or neurodegenerative diseases.
Q: 5: Is Lactacystin reversible, and how long does its effect last?
A: Lactacystin irreversibly binds to the proteasome, leading to prolonged inhibition. The duration of its effect depends on cellular conditions, but it typically lasts until new proteasome molecules are synthesized.

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