SG3249 (CAT#: ADC-S-031)

Linker-Toxin SET, this set is made by Pyrrolobenzodiazepine (PBDs) conjugated to the lysosomally cleavable dipeptide, valine-citrulline (vc) linker. PBDs are a class of DNA-crosslinking agents that are significantly more potent than systemic chemotherapeutic drugs.

Product Information

CAS NO
1595275-62-9

Description
Linker-Toxin SET, this set is made by Pyrrolobenzodiazepine (PBDs) conjugated to the lysosomally cleavable dipeptide, valine-citrulline (vc) linker. PBDs are a class of DNA-crosslinking agents that are significantly more potent than systemic chemotherapeutic drugs.

Molecular Weight
1496.65

Purity
95%

For Research Use Only. NOT FOR CLINICAL USE.

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Excellent

Creative Biolabs' SG3249 exceeded our expectations in ADC research. The PBD-based linker-toxin set provided highly potent DNA crosslinking, delivering precise and strong cytotoxicity in our cancer cell studies.

Excellent

Using SG3249 from Creative Biolabs greatly improved our antibody-drug conjugate development. The PBD-linker system provided exceptional potency with precise targeting, leading to significantly enhanced cytotoxic effects in our experiments.

Excellent

Creative Biolabs' SG3249 has been a game-changer for our ADC projects. The potent DNA-crosslinking ability of the PBDs, coupled with the stable vc linker, made targeting cancer cells more effective and efficient.

Excellent

Our research saw remarkable improvements with Creative Biolabs' SG3249. The combination of PBDs and the vc linker led to potent DNA damage in cancer cells, enhancing the efficiency and selectivity of our ADC treatments.

Excellent

SG3249 by Creative Biolabs provided excellent results in our lab. The PBD-toxin's high potency, combined with the cleavable vc linker, led to significant cytotoxicity with precision in our targeted cancer therapy research.

Q: 1: What is SG3249 and how is it used in research?
A: SG3249 is a potent cytotoxic agent used in antibody-drug conjugates (ADCs) to target cancer cells. It works by binding to tubulin, disrupting microtubule formation, leading to apoptosis, and is widely applied in preclinical oncology research.
Q: 2: How does SG3249 compare to other cytotoxic agents?
A: SG3249 is highly specific in its action, effectively targeting cancer cells by inhibiting mitotic processes. Its mechanism, which involves microtubule disruption, makes it distinct from DNA-damaging agents like doxorubicin or alkylating compounds.
Q: 3: How is SG3249 typically conjugated to antibodies?
A: SG3249 is conjugated to antibodies via a cleavable linker, which ensures that the drug is selectively released in the tumor microenvironment. This approach allows researchers to target cancer cells while sparing healthy tissue.
Q: 4: How does Creative Biolabs optimize SG3249 for ADC development?
A: Creative Biolabs optimizes SG3249 for antibody-drug conjugate development by providing high-purity synthesis and consistent batch quality, ensuring stable conjugation and effective cytotoxicity, ideal for targeted cancer research applications.
Q: 5: In what cancer research areas is SG3249 commonly studied?
A: SG3249 is commonly studied in cancer research involving hematologic malignancies, such as non-Hodgkin's lymphoma and multiple myeloma, as well as solid tumors like breast cancer. Its role in antibody-drug conjugates (ADCs) makes it valuable for developing targeted therapies that minimize harm to healthy cells.

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