Creative Biolabs is a leading service provider that focuses on polyclonal, monoclonal, and recombinant antibody development for research, diagnosis, and potential therapeutics. Based on our extensive experience and state-of-the-art platforms, Creative Biolabs now offers a series of biomarker-specific IVD (in vitro diagnostic) antibody development services to clients globally. Especially, we introduce our IVD antibody development services for melatonin marker.
Melatonin, N-acetyl-5-methoxy tryptamine, is a kind of hormone that is generated by the pineal gland in animals, which regulates wakefulness and sleep. Melatonin can be also generated in plants where it functions as a first defense against oxidative stress. In animals, melatonin takes part in the entrainment of the circadian rhythms, such as blood pressure regulation, sleep-wake timing, and seasonal reproduction. Many of the biological effects in animals are generated through activation of melatonin receptors, while others are due to its role as an antioxidant.
Sleep Disorders Induced by Melatonin
Melatonin has been studied for insomnia in the elderly for many years. Short-term treatment of melatonin was found to be safe and effective in improving sleep quality, latency, and daytime alertness. But no evidence has been found that melatonin can help sleep problems in people with moderate to severe dementia because of Alzheimer's disease.
Functions of Melatonin for Immune system
It is recognized that melatonin interacts with the immune system, including anti-inflammatory effect. Positive immunological effect is regarded to be the result of melatonin acting on high-affinity receptors, such as MT1 and MT2, which expressed in immunocompetent cells. In preclinical studies, melatonin can enhance cytokine production, and by doing this, counteract acquired immune deficiencies. Besides, it is suggested that melatonin can be useful in fighting infectious disease including bacterial infections, viral infections and potentially in the treatment of cancer.
Other Adverse Effects Caused by Melatonin Disorder
Melatonin disorder can cause irritability, nausea and next-day grogginess. In the elderly, it can cause hypothermia and reduced blood flow. In autoimmune disorders, melatonin supplementation may ameliorate or exacerbate symptoms due to immunomodulation level. It is shown that melatonin can reduce follicle-stimulating hormone levels. In addition, anticoagulants and other substances are known to interact with melatonin, which may cause diseases.
Melatonin as a Biomarker for Diseases
Based on the previous studies focusing on the role and functions of melatonin in metabolic system and certain associated conditions, melatonin is now thought to be a novel biomarker in several disorders and diseases mentioned above.
Fig.1 Melatonin pineal gland melatonin and sleep.1
In recent years, IVD technology is undergoing rapid development. IVD antibodies have been widely used in immunodiagnostic tools to aid in the diagnosis of various diseases, conditions, and infections. With years of experience and advanced technology, Creative Biolabs is able to provide a full range of high-quality and cost-effective biomarker-specific antibody development services. Especially, we help develop novel anti-melatonin antibodies for your IVD projects. Having completed a number of IVD antibody generation and development projects, Creative Biolabs is confident to offer you the best products and services to promote your project a success. If you are interested in the services we provide, please don't hesitate to contact us or directly send us an inquiry.
Reference
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