As a world-leading service provider of antibody development and generation, Creative Biolabs is ready to provide a whole series of biomarker-specific in vitro diagnostic (IVD) antibody development services. A team of experienced scientists focused on antibody development are pleased to assist you in your project in a timely and cost-effective manner. Here, we introduce our IVD antibody development services targeting progesterone marker.
In mammals, progesterone, like all other steroid hormones, is synthesized from pregnenolone, which itself is derived from cholesterol. It plays a significant part in the menstrual cycle, pregnancy, and embryogenesis of humans or other species. It is one of the primary sex hormones in the body. Besides, progesterone is also a necessary metabolic intermediate required in the generation of other endogenous steroids, such as corticosteroids.
Hormonal Interactions between Progesterone with Others
Progesterone has a lot of physiological effects that are well functioning in the presence of estrogens. Estrogen receptors (ERs) are thought to induce or regulate the function of the progesterone receptor. In breast tissue, estrogen allows progesterone to mediate the development of lobuloalveolar. Increased levels of progesterone potently down-regulate the sodium-retaining activity of aldosterone, which lead to the natriuresis and as a consequence, a reduction in extracellular fluid volume. Progesterone withdrawal is related to a temporary increase in sodium retention, because of the compensatory increase in aldosterone production, combating the blockade of the mineralocorticoid receptor by the elevated level of progesterone.
Functions of Progesterone for Reproductive System
Progesterone has major effects via non-genomic signal on human sperm as they migrate through the female tract before fertilization occurs, through the receptors. Detailed characterization of the events occurs in sperm in response to progesterone, which has elucidated certain events including intracellular calcium transients as well as maintained changes. Slow calcium oscillations are thought to regulate motility, which is produced by the ovaries. In addition, progesterone has also been shown to demonstrate effects on octopus spermatozoa.
Fig.1 H&E stain micrograph revealing progesterone-induced changes in the endometrium.1
Functions of Progesterone for Breast
Progesterone also seems to be involved in the pathophysiology of breast cancer. In many cases, especially synthetic progesterone, like medroxyprogesterone acetate, in combination with estrogen has been found to significantly increase the risk of breast cancer in postmenopausal women. But the combination of natural progesterone with estrogen has been found not to do so.
Progesterone as a Biomarker for Diseases
Based on the previous studies focusing on the role and functions of progesterone in metabolic system and certain associated conditions, progesterone is now thought to be a novel biomarker in several disorders and cancers mentioned above.
IVD antibodies have been commonly used in immunodiagnostic kits for disease diagnosis and prognosis. Creative Biolabs has built a versatile IVD platform to provide custom biomarker-specific IVD antibody development services to global clients. Moreover, we also offer one-stop diagnostic immunoassay development services including feasibility analysis, assay design, assay protocol establishment, validation, and production. Along with over a decade of rich experience in providing excellent custom services for IVD antibody discovery, our services can totally meet your special requirements. If you are interested in our services, please do not hesitate to contact us for more details.
Reference
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