Creative Biolabs is one of the well-recognized experts who are professional in the field of in vitro diagnostic (IVD) antibody discovery against various cardiovascular markers. Based on our advanced technology platforms and years of experience, now we offer customized IVD antibody development services against different disease biomarkers for our clients all over the world, such as the S-adenosylhomocysteine (SAH) marker.
Homocysteine is one kind of thiol amino acid which plays an important role in methionine metabolism. Methionine can be activated to form S-adenosylmethionine (SAM) with the help of ATP. The SAM, reacting with protein arginine methyltransferases which can produce methylarginines, serves as the donor for methyltransferases. SAH is the metabolic precursor of nearly all homocysteine which can be mainly produced via SAM-dependent methyl transfer reactions. Moreover, SAH has the ability to form homocysteine according to the hydrolysis. In previous research, the ratio of SAM: SAH is used as the indicator for the potential of cellular methylation as SAM and SAH are necessary substrate and product for the methyltransferase reactions. In recent years, SAH has been found to be a high-efficient biomarker for the association between chronic kidney disease (CKD) and cardiovascular disease (CVD).
Fig 1. Summary illustration of methionine metabolic pathways. (Dash, 2016)
SAH Marker of Chronic Kidney Disease and Cardiovascular
CKD is a type of kidney disease which has no symptoms in the early stage but loses the kidney function gradually over a period of months and years. The complications of CKD always include anemia, heart disease, bone disease, high blood pressure, and cardiovascular disease. It has been studies that the patients with CKD are more likely to die of CVD rather than the kidney failure. In this case, the prevention and treatment of CVD have been major considerations for the patients with CKD. In recent years, it has been reported that the serum level of SAH is remarkably increased in the patients with CKD. And the concentration level of SAH in CKD males is always higher than females even there is nearly no difference for SAM.
IVD antibodies have been widely used in the diagnosis of numerous diseases. Antibody-based immunoassays are the most generally used diagnostic assays for the detection of biomolecules. With advanced technology and professional scientists, Creative Biolabs is capable of offering a full range of IVD antibody development services against various markers for global customers. In addition, Creative Biolabs provides one-stop diagnostic immunoassay development services, including feasibility analysis, assay design, assay protocol establishment, validation, and production. For more details and information, please feel free to contact us and get a quote.
Reference
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