Creative Biolabs is a well-recognized expert in the field of antibody generation and production. Especially, we have launched a series of in vitro diagnostic (IVD) antibody& immunoassay development services for different pathogens and disease biomarkers. Scientific progress has resulted in the discovery of more and more novel disease biomarkers to fulfill the need for a quicker, more specific, and more accurate diagnosis. Particularly, TYMP is one of the potential biomarkers for cancer diagnosis.
Thymidine phosphorylase (TYMP), also known as the platelet-derived endothelial cell growth factor (PD-ECGF) orgliostatin, is a key enzyme in the pyrimidine salvage pathway to ensure that sufficient pyrimidine nucleotides are available for DNA repair and replication. It is overexpressed in several human cancers in response to cellular stressful conditions like hypoxia, acidosis, chemotherapy, and radiotherapy. In addition to its metabolic function, TYMP plays a key role in tumor angiogenesis, invasion, metastasis, evasion of the immune response, and resistance to apoptosis.
Fig.1 TYMP in possible mechanism of biochemical correction by gene-modified HSCs.1
Angiogenesis is a very critical process in repairing tissues and organs, especially in tumor formation. It is believed that tumor growth could be blocked by stopping angiogenesis. Whereas, TYMP can promote new capillary blood vessel formation and regulate the levels of endogenous thymidine to influence fluorothymidine uptake. And it has been found that the TYMP expression level is elevated in various solid tumors where it is likely involved in mechanisms that regulate cell proliferation and apoptosis. Besides, a high level of TYMP expression in tumor cells usually indicates poor prognoses. Therefore, TYMP can be used as a biomarker to aid in the diagnosis of many cancers, such as follicular adenoma, breast cancer. Interestingly, TYMP also plays a role in cancer treatment and is a predictive marker for fluoropyrimidine response.
Creative Biolabs has accumulated years of experience producing antibodies and immunoassay reagents for different biomarkers. We have established a comprehensive IVD platform to offer unparalleled custom-specific IVD antibody development services and we also offer one-stop immunoassay development services to global clients. We have expertise in different technology platforms, such as turbidimetric assays, chemiluminescent assays, ELISA assays, and rapid tests. Our services cover the full process of an immunoassay development, including recombinant protein production, antibody development, conjugation, and immunoassay design, development, validation, and production. For more information, please click the links below:
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Reference
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