Recent data in pathogenic fungi of humans has stressed the importance of antifungal studies and arouse the interest of researchers in antifungal drug discovery. Pathways of amino acids biosynthesis in human pathogenic fungi have been regarded as a new source of targets for antifungal agent discovery. Now, Creative Biolabs can offer the identification services of potential targets for antifungal drug discovery, especially for homoserine transacetylase.
Homoserine Transacetylase
Homoserine transacetylase (referred to as HTA for short), which is also known as homoserine acetyltransferase, homoserine O-acetyltransferase, homoserine-O-transacetylase, and L-homoserine O-acetyltransferase, is an enzyme that catalyzes an essential step in the serine biosynthesis pathway. HTA belongs to the family of transferases which is part of the GHMP kinase superfamily, particularly those acyltransferases transferring groups other than aminoacyl groups. It plays a role in methionine metabolism and sulfur metabolism. HTA enzyme has proved to catalyze one of the required steps in the biosynthesis of methionine in fungi and several bacteria.
Fig.1 Crystal Structure of Homoserine Transacetylase.
Homoserine Transacetylase as a Target for Antifungal Drug Discovery
The conserved subset of amino acid biosynthetic enzymes in fungi, which is not present in human, shows exciting potential as underexploited antifungal drug targets. Particularly, the biosynthesis of methionine (Met) has been suggested to be susceptible to small-molecule inhibition in fungi. Met is essential for cell growth due to its importance for several biochemical processes. Met is synthesized in bacteria, fungi, and plants via the Asp biosynthetic pathway. Several component enzymes in Asp biosynthetic pathway have been considered as novel antifungal targets. The first committed step in Met biosynthesis is identified as the acylation of homoserine (Hse) by the enzyme HTA. Recent data has also validated HTA as a promising drug-susceptible target for new antifungal drug development.
Why Choose Us?
With years of experience and advanced technology, scientists in Creative Biolabs are willing to assist you in your antifungal studies, for seeking different targets in various pathways of fungal nucleic acid and protein biosynthesis as possible routes for antifungal drug discovery. Now, we can provide various identification services for Fungal Nucleic Acid and Protein Biosynthesis Targets as follows:
In addition to the identification of fungal nucleic acid and protein biosynthesis targets, you might be also interested in other services for Potential Targets for Antifungal Drug Discovery listed below:
If you have any special needs in discovering potential targets for antifungal drugs or be interested in learning more about our antifungal drug discovery services, please feel free to contact us for more details.
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