Invasive fungal infections caused by opportunistic fungal pathogens have become a global problem that arouses much concern since they are related to increased morbidity and mortality. Therefore, antifungal drug discovery is supposed to be another area of great concern. As an international leading company in the industry of drug discovery, Creative Biolabs provides target identification and validation services, especially for threonine synthase as a potential target.
Threonine Synthase
The threonine synthase (TS), which is also known as O-phospho-L-homoserine phospho-lyase (adding water), is a pyridoxal 5′-phosphate (PLP)-dependent enzyme that acts on phosphates. It belongs to the family of lyases, specifically those carbon-oxygen lyases. TS plays a role in the metabolism process of glycine, serine, and threonine, as well as vitamin B6.
Fig.1 Structural features of the yeast TS monomer. (Garrido-Franco, 2002)
Threonine Synthase as a Target for Antifungal Drug Discovery
Because the fungal enzymes play a critical role in the fungal growth and establishment in the host, they are considered as one of the most significant and potential targets for novel drug development. TS is proved to catalyzes the ultimate step of threonine biosynthesis, the pyridoxal 5'-phosphate (PLP)-dependent conversion of O-phosphohomoserine into inorganic phosphate and threonine. Threonine is a fundamental nutrient for mammals, and its biosynthetic machinery is restricted to bacteria, fungi, and plant. Thus, TS is supposed to be an interesting pharmaceutical target.
Additionally, the importance and potential of this target have been chemically validated since the natural products rhizocticin have been shown to target TS and inhibit the growth of fungi. To date, numerous substrate analogs have been validated as putative mechanism-based inhibitors of TS.
Why Choose Us?
Creative Biolabs has brought together the world leading expertise to build our antifungal drug discovery team. Now, we provide the best strategy and protocols customized to suit any antifungal drug discovery project, especially for Fungal Nucleic Acid and Protein Biosynthesis Targets, including:
In addition to the identification of potential targets for antifungal drug discovery, you might be also interested in other services for Potential Targets for Antifungal Drug Discovery listed below:
If you have any special needs in discovering potential targets for antifungal drugs or be interested in learning more about our antifungal drug discovery services, please feel free to contact us for more details.
Reference
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