Creative Biolabs offers a full package of in vitro pharmacodynamics services for numerous drug candidates. Particularly, we offer high-quality neurological drug pharmacodynamics evaluation services for global customers. With more than ten years of industry experience, our scientists guarantee to help your product reach development milestones faster and effectively.
The neurodegenerative diseases comprise a class of brain diseases, which include diseases like Alzheimer’s Disease, Huntington’s Disease, Amyotrophic Lateral Sclerosis (ALS), Parkinson’s Disease, Pick’s Disease, etc. For a long period, the treatment of these neurodegenerative brain disorders is a challenging task because the inadequate understanding or consideration of a number of factors, such as the complexity of brain anatomy and function, the neuro-PK with regard to blood-brain barrier (BBB) transport and intra-brain distribution as well as the measures to study these processes, adequate biomarkers of central nervous system (CNS) drug effects (neuro-PD), and the complex nature of CNS diseases. Especially, the major cause for the failure in the treatment of the diseases is ineffective drug delivery to the CNS.
Fig.1 Promise of hiPSCs. Schematic representation of how somatic cells taken from patient factors, OCT4, KLF4, c-MYC, and SOX2. Subsequent differentiation of human iPSCs (hiPSCs) into n fication of potential drug targets. In addition, hiPSC derived neurons may function as a cellular. (Shum, C., 2015)
Generally, drug efficacy is determined through animal models before clinical trials. However, it is costly and not so accurate to predict the efficacy of drugs for nervous system disorders as the differences between animals and humans in cell types, transmitter function, and anatomy. With the rapid development of technology, more and more top tools and technologies have been applied to further elucidate mechanisms of diseases and assist in identifying and validating drug targets. For example, stem cell technologies can be used to model “human” disease pathology at the cellular level and, in some cases, maybe a faster and better alternative to animal models. Furthermore, computational neuroscience in conjunction with neuroimaging might aid in understanding the underlying neurobiological mechanisms of diseases.
With years of experience in the field of neurological drug discovery, Creative Biolabs is capable of offering a full package of cell-based in vitro pharmacodynamics study for our clients all over the world, including but not limited to:
Creative Biolabs is dedicated to promoting the development of global customers’ neurological drug discovery projects. Our experienced scientists are happy to share their expert knowledge to make your program a success. If you need our help, please feel free to contact us for more information or directly get a quote.
Reference
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