Osteoporosis is a disease characterized by low bone mass and structural deterioration of bone tissue, leading to bone fragility and an increased susceptibility to fractures. The incidence of osteoporosis increases with age and occurs most frequently in postmenopausal women due to the dramatic estrogen withdrawal associated with menopause. Animal models of postmenopausal bone loss induced with ovariectomy provided by Creative Biolabs present characteristics of bone loss and its sequelae resembles those found in postmenopausal women in some respects due to ovarian hormone deficiency. As a consequence, this model is widely applied for studying problems that are relevant to postmenopausal bone loss.
The Ovariectomized Rat Model
For induction of bone loss, female rats with 3 months of age are ovariectomized. Although the skeletal growth is continued, studies have proved that the rats are sexually mature at this time of age and is sufficient to induce bone loss. About 3 months after ovariectomy, robust ovariectomy-induced pathological changes to the bone structure at different sites, including the proximal tibia, femur neck, and lumbar vertebrae.
Similarities Shared with Postmenopausal Bone Loss
Features of the Ovariectomized Rat Model
Assessments
In testing the therapeutic efficacy of osteoporosis drug candidates, we are capable of conducting all kinds of assessments as well as providing assistance in data interpretation. Our battery of assessments including but not limited to:
Additionally, other examples of rodent musculoskeletal disease models that you may be interested include:
Supported by a team of experts with years of experience in the field of musculoskeletal research and surgeons who are skilled in animal surgery, Creative Biolabs is proud to provide a comprehensive list of drug efficacy testing services. Particularly, we are willing to share our expertise and work with you to design and develop experimental models with the highest clinical relevance. If you're interested in our services, contact us for more information.
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