shRNA Adenovirus Serotype 5 (ΔE1/E3), p7SK-(GEMIN8-shRNA-Seq1)(CAT#: AdV-SI1171WQ)

This product is a GEMIN8-shRNA encoding AdV, which is based on AdV-5 serotype with EIB-55K gene deleted. The protein encoded by GEMIN8 gene is part of the SMN complex, which is necessary for spliceosomal snRNP assembly in the cytoplasm and pre-mRNA splicing in the nucleus. The expression of GEMIN8-shRNA leads to target gene silencing and this product can be used in gene therapy research and development.

Specifications
Family Adenoviridae
Species Adenovirus
Serotype HAdV-5
Backbone AdV-5 (ΔE1/E3)
Tropism Both nondividing and dividing cells
Insert GEMIN8-shRNA-Seq1
Related Target/Protein GEMIN8
Region CDS
TargetSeq GAGTCAGATGCAGAGGTAGAA
NCBI RefSeq NM_017856
Alternative Names FAM51A1
Titer >1*10^10 GC/mL
Related Diseases Survival motor neuron (SMN)
Target Gene
Gene ID 54960
Uniprot ID Q9NWZ8

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