shRNA Adenovirus Serotype 5 (ΔE1/E3), p7SK-(PRRC2A-shRNA-Seq1)(CAT#: AdV-SI1395WQ)
This product is a PRRC2A-shRNA encoding AdV, which is based on AdV-5 serotype with EIB-55K gene deleted. The PRRC2A gene has microsatellite repeats which are associated with the age-at-onset of insulin-dependent diabetes mellitus (IDDM) and possibly thought to be involved with the inflammatory process of pancreatic beta-cell destruction during the development of IDDM. The expression of PRRC2A-shRNA leads to target gene silencing and this product can be used in gene therapy research and development.
Specifications | |
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Family | Adenoviridae |
Species | Adenovirus |
Serotype | HAdV-5 |
Backbone | AdV-5 (ΔE1/E3) |
Tropism | Both nondividing and dividing cells |
Insert | PRRC2A-shRNA-Seq1 |
Related Target/Protein | PRRC2A |
Region | CDS |
TargetSeq | CCTCGCTCAACCTGTTTGATA |
NCBI RefSeq | NM_004638 |
Alternative Names | G2; BAT2; D6S51; D6S51E |
Titer | >1*10^10 GC/mL |
Related Diseases | Insulin-dependent diabetes mellitus (IDDM) |