shRNA Adenovirus Serotype 5 (ΔE1/E3), pH1-(PIGW-shRNA-Seq2)(CAT#: AdV-SI0641WQ)
This product is a PIGW-shRNA encoding AdV, which is based on AdV-5 serotype with EIB-55K gene deleted. The protein encoded by PIGW gene is an inositol acyltransferase that acylates the inositol ring of phosphatidylinositol. Defects in this gene are a cause of the age-dependent epileptic encephalopathy West syndrome as well as a syndrome exhibiting hyperphosphatasia and cognitive disability (HPMRS5). The expression of PIGW-shRNA leads to target gene silencing and this product can be used in gene therapy research and development.
Specifications | |
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Family | Adenoviridae |
Species | Adenovirus |
Serotype | HAdV-5 |
Backbone | AdV-5 (ΔE1/E3) |
Tropism | Both nondividing and dividing cells |
Insert | PIGW-shRNA-Seq2 |
Related Target/Protein | PIGW |
Region | 3UTR |
TargetSeq | GCAACAGTGTTAACCATATTT |
NCBI RefSeq | NM_178517 |
Alternative Names | Gwt1; HPMRS5 |
Titer | >1*10^10 GC/mL |
Related Diseases | Hyperphosphatasia and mental retardation syndrome |