shRNA Adenovirus Serotype 5 (ΔE1/E3), pU6-(LAMP3-shRNA-Seq2)(CAT#: AdV-SI0240WQ)
This product is a LAMP3-shRNA encoding AdV, which is based on AdV-5 serotype with EIB-55K gene deleted. LAMP3 regulates hepatic lipid metabolism through activating PI3K/Akt pathway. LAMP3 promotes the invasion of osteosarcoma cells via SPP1 signaling. LAMP3 expression correlated with poor clinical outcome in human ovarian cancer. The expression of LAMP3-shRNA leads to target gene silencing and this product can be used in gene therapy research and development.
Specifications | |
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Family | Adenoviridae |
Species | Adenovirus |
Serotype | HAdV-5 |
Backbone | AdV-5 (ΔE1/E3) |
Tropism | Both nondividing and dividing cells |
Insert | LAMP3-shRNA-Seq2 |
Related Target/Protein | LAMP3 |
Region | CDS |
TargetSeq | GTCTCAGATCCAGAGACAATT |
NCBI RefSeq | NM_014398 |
Alternative Names | LAMP; CD208; DCLAMP; LAMP-3; TSC403; DC LAMP; DC-LAMP |
Titer | >1*10^10 GC/mL |
Related Diseases | Oral squamous cell carcinoma |