shRNA Adenovirus Serotype 5 (ΔE1/E3), pU6-(PRR14-shRNA-Seq2)(CAT#: AdV-SI0433WQ)
This product is a PRR14-shRNA encoding AdV, which is based on AdV-5 serotype with EIB-55K gene deleted. The protein encoded by PRR14 gene tethers heterochromatin to the nuclear laminar scaffold by binding heterochromatin protein 1 (HP1) and the nuclear lamina. The expression of PRR14-shRNA leads to target gene silencing and this product can be used in gene therapy research and development.
Specifications | |
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Family | Adenoviridae |
Species | Adenovirus |
Serotype | HAdV-5 |
Backbone | AdV-5 (ΔE1/E3) |
Tropism | Both nondividing and dividing cells |
Insert | PRR14-shRNA-Seq2 |
Related Target/Protein | PRR14 |
Region | CDS |
TargetSeq | CTCCTGGAGGAAGAAACAGTA |
NCBI RefSeq | NM_024031 |
Titer | >1*10^10 GC/mL |
Related Diseases | Lung cancer |