Recombinant adenovirus, pU6-(Human NLRP3), Overexpression(CAT#: AdV-GTOH0053WQ)
The product is an adenovirus vector containing the insertion of NLRP3 gene. This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. The product is suitable for stable overexpression of exogenous gene in various types of cells and can be used in gene therapy research and development.
| Specifications | |
|---|---|
| Family | Adenoviridae |
| Species | Adenovirus |
| Tropism | Both nondividing and dividing cells |
| Insert | NLRP3 |
| Related Target/Protein | Human NLRP3 |
| NCBI RefSeq | NM_001079821 |
| Alternative Names | AII, AVP, FCU, MWS, FCAS, KEFH, CIAS1, FCAS1, NALP3, C1orf7, CLR1.1, DFNA34, PYPAF1, AGTAVPRL |
| Titer | >1.00E+10 PFU/mL |
| Related Diseases | familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID) |
| Application | Overexpression |
