Gene Therapy Development for Cancer
The rapidly changing field of gene therapy brings a number of innovative treatment strategies for cancer patients and has shown remarkable therapeutic benefits and an excellent safety record in the clinical trials. Advances in multiple gene therapy strategies such as genetic modification of cancer and immune cells and the use of oncolytic viruses and bacteria have deeply promoted the application of gene therapy in the cancer. At Creative Biolabs, our team has the world-class scientists who can help you design a flexible, data-driven approach for preclinical efficient testing programs according to your objective. In addition, various popular cancer gene therapy products can also be provided for our clients all over the world. The highlights of cancer gene therapy service platforms are shown as follows.
Featured Cancer Gene Therapy Development Categories
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Immunotherapy
By boosting the immune system to target and destroy cancer cells, immunotherapy has achieved many satisfactory results and a wide array of gene therapy techniques are used for cancer treatment, such as recombinant cancer vaccines, the delivery of immunostimulatory genes (mainly cytokines), checkpoint inhibitors, monoclonal antibodies and the adoptive cell transfer, etc. Our one-stop services refer to the entire immunotherapy development process, which can greatly assist in your research, preclinical investigation and clinical stage development.
Figure 1. Schematic diagram of immunotherapy (Cross 2006)
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Oncolytic Therapy
Another growing area of gene therapy for cancer is the use of specially modified viruses that target and destroy cancer cells while leaving normal cells unharmed. Generally, the viral vectors are engineered to contain certain oncolytic gene to target and destroy cancer cells. In animal studies and clinical trials, oncolytic therapy has achieved promising results in a variety of cancers, including bladder, malignant glioma and squamous cell cancers of the head and neck, etc. As a world-leading expert in oncolytic therapy, Creative Biolabs has developed the advanced OncoVirapy™ platform in-house for our clients to meet their research needs.
Figure 2. Schematic diagram of oncolytic virotherapy (Cross 2006)
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Gene Transfer
Gene transfer or insertion is one of the most exciting treatments, which emerges from the concept of gene therapy by introducing a foreign gene directly into cancer cells or surrounding tissue. Different functional genes have been used, including suicide genes, antiangiogenesis genes and cellular stasis genes. In addition, a number of different viral and non-viral vectors are used to explore in preclinical and clinical researches to deliver these genes. Creative Biolabs possesses the most advanced techniques and years of experiences in the field of gene transfer therapy and can provide new delivery methods and more sophisticated gene expression cassettes for customers.
Figure 3. Schematic diagram of gene transfer therapy (Cross 2006)
The emerging field of cancer gene therapy provides numerous exciting potential treatments. With professional scientists and various technology platforms at Creative Biolabs, we provide our clients with the best-characterized cancer gene therapy development services including the preclinical in vitro and in vivo validation. All of our studies are performed in a GLP-compliant and IACUC-regulated facility by experienced technicians to help our clients to expedite their research in clinical trials. Please do not hesitate to contact us for more information.
Reference
- Cross, D. and Burmester, J. (2006). Gene Therapy for Cancer Treatment: Past, Present and Future. Clinical Medicine & Research, 4(3), pp.218-227.