shRNA Lentivirus (self-inactivating), pU6-(TCTN3-shRNA-Seq1)(CAT#: LV-SI2243WQ)

This product is a TCTN3-shRNA encoding Lentivirus, which is based on HIV-1 serotype. The TCTN3 gene encodes a member of the tectonic gene family which functions in Hedgehog signal transduction and development of the neural tube. Mutations in this gene have been associated with Orofaciodigital Syndrome IV and Joubert Syndrom 18. The expression of TCTN3-shRNA leads to target gene silencing and this product can be used in gene therapy research and development.

Specifications
Family Retroviridae
Species Lentivirus
Serotype HIV-1
Backbone Lenti-SIN
Tropism Both nondividing and dividing cells
Insert TCTN3-shRNA-Seq1
Related Target/Protein TCTN3
Region CDS
TargetSeq CATACCAGTTTCCCTGGAGAT
NCBI RefSeq NM_015631
Alternative Names OFD4; TECT3; JBTS18; C10orf61
Titer >1*10^10 GC/mL
Related Diseases Orofaciodigital Syndrome IV and Joubert Syndrom 18
Target Gene
Gene ID 26123
Uniprot ID Q6NUS6

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