Drug Distribution Analysis Service

Drug distribution specifically refers to that a drug is spread and transported throughout the various tissues and organs in the body after it is absorbed into the bloodstream. Drug distribution analysis in vitro is a crucial step in the drug development process. The distribution assays help researchers predict how a drug will behave in vivo, or in a living organism. It is crucial to understand the pharmacokinetic properties of a drug and determine the effective dose of a drug, its safety profile, and its potential therapeutic efficacy. At Creative Biolabs, we provide comprehensive distribution analysis services to help our clients understand the pharmacokinetic behavior of their drugs. Our team of experienced scientists has extensive knowledge in drug distribution analysis and offers consulting services to help you tailor drug distribution assay solutions and interpret the results of your distribution assays.

Distribution Assays

At Creative Biolabs, our drug distribution analysis services are designed to simulate the physiological conditions of the human body, providing insights into how drugs interact with tissues and organs. Using state-of-the-art instrumentation and validated methods, we analyze the distribution of drugsin vitro, allowing for predictions of in vivo behavior. Several in vitro drug distribution assays are available at our lab including:

• Protein Binding Assays
  Protein binding can affect the distribution of a drug in the body. At Creative Biolabs, we typically use blood, microsomes, tissue homogenates, and animal or human cells to study the distribution of a drug in specific cell types or tissues. To determine the drug distribution, we offer the following protein binding assays:
  
  • Plasma Protein Binding Assay
  • Whole Blood Binding Assay
  • Brain Tissue Binding Assay
  • Hepatocyte Binding Assay
  • Microsomal Binding Assay
• Red Blood Cell (RBC) Partitioning Assay
  Red blood cells can serve as a reservoir for certain drugs, affecting their overall distribution and pharmacokinetics in the body. The RBC partitioning assay provides valuable insights into the distribution of drugs within the blood compartment, specifically the ratio of whole blood to plasma. It can help in understanding the extent to which a drug binds to red blood cells, which may affect its distribution to different organs and tissues.

FAQ

1. What species do your blood/tissue samples come from?
   At Creative Biolabs, our blood/tissues are from several species including human, rodent, and nonrodent species such as human, mouse, rat, rabbit, and monkey.
2. What method do you use to analyze Plasma Protein Binding?
   Plasma protein binding of compounds is frequently evaluated using a range of techniques, such as equilibrium dialysis, ultrafiltration, ultracentrifugation, and flux dialysis. Equilibrium dialysis is the most common method among them. The choice of method depends on the specific drug properties and the needs of your projects.

For Research Use Only | Not For Clinical Use